CAJ | 학술논문

目的探讨帕金森病患者血浆尿酸、尿微量白蛋白水平与疾病进展及认知功能障碍的关系.方法回顾性分析2007年1月至2014年4月在我院内科门诊及住院部就诊并确诊为帕金森病(PD)的患者102例作为PD组,按发病年龄早晚分为早发病组、晚发病组,按认知功能障碍评估情况分为PD伴认知功能障碍组及PD不伴认知功能障碍组,根据运动功能障碍评估分为Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ期,Ⅰ～Ⅱ期为早期、Ⅲ期为中期、Ⅳ～Ⅴ期为晚期;并将我院体检中心进行体检的102名健康者作为对照组.对各组人员进行血浆尿酸、尿微量白蛋白水平的检测.进行统计学处理,各亚组间及与对照组进行对比.结果 PD病例组血尿酸水平明显低于对照组(P＜0.01).早发病组与晚发病组比较,血尿酸水平无统计学差异(P＞0.05);PD伴认知功能障碍组血尿酸水平低于不伴认知功能障碍组(P＜0.05);早中晚各期患者血尿酸水平无统计学差异(P＞0.05);各亚组血尿酸水平均低于对照组.各亚组间及各亚组与对照组比较尿微量白蛋白水平无统计学差异(P＞0.05).结论帕金森病患者血浆尿酸水平低于健康者,低血浆尿酸水平可能是帕金森病的危险因素之一.血浆尿酸水平减低与帕金森病的疾病进展无明显相关性,但可能与认知功能损伤有关.尿微量白蛋白与帕金森病的发生与发展无明显相关.对血尿酸水平进行适当干预可能有助于提高帕金森病患者的生活质量,并节省医疗费用.
목적 탐토파금삼병환자혈장뇨산、뇨미량백단백수평여질병진전급인지공능장애적관계.방법 회고성분석2007년1월지2014년4월재아원내과문진급주원부취진병학진위파금삼병(PD)적환자102례작위PD조,안발병년령조만분위조발병조、만발병조,안인지공능장애평고정황분위PD반인지공능장애조급PD불반인지공능장애조,근거운동공능장애평고분위Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ기,Ⅰ～Ⅱ기위조기、Ⅲ기위중기、Ⅳ～Ⅴ기위만기;병장아원체검중심진행체검적102명건강자작위대조조.대각조인원진행혈장뇨산、뇨미량백단백수평적검측.진행통계학처리,각아조간급여대조조진행대비.결과 PD병례조혈뇨산수평명현저우대조조(P＜0.01).조발병조여만발병조비교,혈뇨산수평무통계학차이(P＞0.05);PD반인지공능장애조혈뇨산수평저우불반인지공능장애조(P＜0.05);조중만각기환자혈뇨산수평무통계학차이(P＞0.05);각아조혈뇨산수평균저우대조조.각아조간급각아조여대조조비교뇨미량백단백수평무통계학차이(P＞0.05).결론 파금삼병환자혈장뇨산수평저우건강자,저혈장뇨산수평가능시파금삼병적위험인소지일.혈장뇨산수평감저여파금삼병적질병진전무명현상관성,단가능여인지공능손상유관.뇨미량백단백여파금삼병적발생여발전무명현상관.대혈뇨산수평진행괄당간예가능유조우제고파금삼병환자적생활질량,병절성의료비용.
Objective To study the relationship of the levels of serum uric acid and urinary microalbumin with the progression and cognitive dysfunction of patients with Parkinson' s disease (PD).Methods A retrospective analysis of 102 confirmed cases of PD (including both outpatients and inpatients of our hospital from January 2007 to April 2014) was carried out.102 patients were divided into early-onset group and late-onset group according to patients' ages at onset,PD with cognitive dysfunction group and PD without cognitive dysfunction group according to the assessment of patients' cognitive dysfunction,Ⅰ stage,Ⅱ stage,Ⅲ stage,Ⅳ stage,Ⅴ stage according to the assessment of patients' motor dysfunction (Ⅰ-Ⅱ stage for early stage,Ⅲ stage for mid-stage,Ⅳ-Ⅴ stage for advanced stage).Besides,102 healthy people who had physical examinations in our hospital were recruited as control group.The levels of serum uric acid and urinary microalbumin were detected,statistically analyzed and compared among sub groups.Results The level of serum uric acid of PD group was significantly lower than that of control group (P ＜ 0.01).There was no statistically significant difference in serum uric acid between early-onset group and late-onset group (P ＞ 0.05).The level of serum uric acid of PD with cognitive dysfunction group was lower than that of PD without cognitive dysfunction group (P ＜ 0.05).There were no statistically significant differences in serum uric acid among early stage,mid-stage,advanced stage (P ＞ 0.05).The levels of serum uric acid of each sub group were all lower than that of control group.There were no statistically significant differences in the level of urinary microalbumin between each sub group and control group (P ＞ 0.05).Conclusions The level of serum uric acid in patients with Parkinson' s disease is lower than that of healthy subjects,and low serum uric acid level may be one of risk factors for Parkinson's disease.There is no significant correlation between low serum uric acid level in Parkinson's disease and the disease progression.However,low uric acid level seems to have something to do with the cognitive impairment in patients with PD.There is no significant correlation between urinary microalbumin and the occurrence and development of Parkinson's disease.Appropriate intervention on blood uric acid level may not only help to improve PD patients' quality of life,but also save their medical expenses.