国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
21期
3269-3272
,共4页
凝血功能指标%胃肠道出血%早产儿%诊断%变化
凝血功能指標%胃腸道齣血%早產兒%診斷%變化
응혈공능지표%위장도출혈%조산인%진단%변화
Coagulant function index%Gastrointestinal hemorrhage%Premature infants%Diagnosis%Change
目的 探讨凝血功能指标在胃肠道出血早产儿中的变化及其临床意义.方法 选取2013年1月至2014年1月期间出生的胃肠道出血早产儿60例,另选取30例同期健康早产儿和足月儿作为对照.统计分析所有新生儿活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、纤维蛋白降解产物(FDP)、D-二聚体(D-D)以及纤维蛋白原(FIB)水平以及胃肠道出血早产儿出生后不同时间段凝血功能指标的变化.结果 胃肠道出血早产儿的血浆APTT、PT、FDP和D-D水平分别为(65.46±18.68)s、(16.54±8.29)s、(8.49±7.65)g/L和(1.07±0.46) mg/L,高于健康早产儿的(52.24±9.75)s、(12.78±7.46)s、(6.48±5.14) g/L和(0.69±0.28)mgm和健康足月儿的(42.73±8.69)s、(10.01 ±7.11)s、(5.87±4.21) g/L和(0.51±0.26) mg/L;而胃肠道出血早产儿的血浆FIB[(2.01±0.75) g/L]低于健康早产儿[(2.36±0.68) g/L]和健康足月儿[(2.49±0.71)g/L],差异有统计学意义(JP＜0.05).胃肠道出血早产儿出生后60、90以及120 d的Am、PT、FDP和D-D水平均较出生时出现不同程度的下降,而血浆FIB则较出生时出现不同程度的上升,差异有统计学意义(P＜0.05).结论 胃肠道出血早产儿存在明显功能障碍,患儿的高凝血因子状态可随着出生后机体的成熟和相应的治疗后缓解.胃肠道出血早产儿凝血功能改变与消化功能密切相关,可在一定程度上预测早产儿胃肠道出血的发生.
目的 探討凝血功能指標在胃腸道齣血早產兒中的變化及其臨床意義.方法 選取2013年1月至2014年1月期間齣生的胃腸道齣血早產兒60例,另選取30例同期健康早產兒和足月兒作為對照.統計分析所有新生兒活化部分凝血酶原時間(APTT)、凝血酶原時間(PT)、纖維蛋白降解產物(FDP)、D-二聚體(D-D)以及纖維蛋白原(FIB)水平以及胃腸道齣血早產兒齣生後不同時間段凝血功能指標的變化.結果 胃腸道齣血早產兒的血漿APTT、PT、FDP和D-D水平分彆為(65.46±18.68)s、(16.54±8.29)s、(8.49±7.65)g/L和(1.07±0.46) mg/L,高于健康早產兒的(52.24±9.75)s、(12.78±7.46)s、(6.48±5.14) g/L和(0.69±0.28)mgm和健康足月兒的(42.73±8.69)s、(10.01 ±7.11)s、(5.87±4.21) g/L和(0.51±0.26) mg/L;而胃腸道齣血早產兒的血漿FIB[(2.01±0.75) g/L]低于健康早產兒[(2.36±0.68) g/L]和健康足月兒[(2.49±0.71)g/L],差異有統計學意義(JP＜0.05).胃腸道齣血早產兒齣生後60、90以及120 d的Am、PT、FDP和D-D水平均較齣生時齣現不同程度的下降,而血漿FIB則較齣生時齣現不同程度的上升,差異有統計學意義(P＜0.05).結論 胃腸道齣血早產兒存在明顯功能障礙,患兒的高凝血因子狀態可隨著齣生後機體的成熟和相應的治療後緩解.胃腸道齣血早產兒凝血功能改變與消化功能密切相關,可在一定程度上預測早產兒胃腸道齣血的髮生.
목적 탐토응혈공능지표재위장도출혈조산인중적변화급기림상의의.방법 선취2013년1월지2014년1월기간출생적위장도출혈조산인60례,령선취30례동기건강조산인화족월인작위대조.통계분석소유신생인활화부분응혈매원시간(APTT)、응혈매원시간(PT)、섬유단백강해산물(FDP)、D-이취체(D-D)이급섬유단백원(FIB)수평이급위장도출혈조산인출생후불동시간단응혈공능지표적변화.결과 위장도출혈조산인적혈장APTT、PT、FDP화D-D수평분별위(65.46±18.68)s、(16.54±8.29)s、(8.49±7.65)g/L화(1.07±0.46) mg/L,고우건강조산인적(52.24±9.75)s、(12.78±7.46)s、(6.48±5.14) g/L화(0.69±0.28)mgm화건강족월인적(42.73±8.69)s、(10.01 ±7.11)s、(5.87±4.21) g/L화(0.51±0.26) mg/L;이위장도출혈조산인적혈장FIB[(2.01±0.75) g/L]저우건강조산인[(2.36±0.68) g/L]화건강족월인[(2.49±0.71)g/L],차이유통계학의의(JP＜0.05).위장도출혈조산인출생후60、90이급120 d적Am、PT、FDP화D-D수평균교출생시출현불동정도적하강,이혈장FIB칙교출생시출현불동정도적상승,차이유통계학의의(P＜0.05).결론 위장도출혈조산인존재명현공능장애,환인적고응혈인자상태가수착출생후궤체적성숙화상응적치료후완해.위장도출혈조산인응혈공능개변여소화공능밀절상관,가재일정정도상예측조산인위장도출혈적발생.
Objective To explore changes of coagulation function index (CFI) in diagnosis of premature babies with gastrointestinal hemorrhage (PBGH) and its clinical significance.Methods 60 PBGHs in our hospital from January 2013 to January 2014 were chosen,and 30 healthy preterm infants and 30 healthy full term infants were selected as control.Activated partial prothrombin time (APTT),prothrombin time (PT),fibrin degradation products (FDP),D-dimer (D-D) and fibrinogen (FIB) levels of all the newborns and CFI of PBGH in different times were statistically analyzed.Results Plasma APTT,PT,FDP and D-D levels of PBGH were (65.46 ± 18.68) s,(16.54 ± 8.29) s,(8.49 ± 7.65) g/L and (1.07 ± 0.46) mg/L respectively,which were higher than those of healthy preterm infants (52.24 ± 9.75) s,(12.78 ± 7.46) s,(6.48 ± 5.14) g/L and (0.69 ± 0.28) mg/L and those of the healthy full-term infants (42.73 ± 8.69) s,(10.01 ± 7.11) s,(5.87 ± 4.21) g/ L and (0.51 ± 0.26) mg/L,and FIB of PBGH was (2.01 ± 0.75) g/L,lower than that of healthy premature infants (2.36 ± 0.68) g/L and that of the healthy full-term infants (2.49 ± 0.71) g/L.The difference was statistically significant (P ＜ 0.05).60 days,90 days and 120 days after birth,APTT,PT,FDP and D-D levels of PBGH are declined while the plasma FIB is increased,and the difference is statistically significant (P ＜ 0.05).Conclusion PBGH has obvious coagulation function disorder; high blood coagulation state of PBGH can be lowered as the growth of baby and treatment.Coagulation function change in PBGH is closely related to its digestive function,which can be used to predict the occurrence gastrointestinal hemorrhage.
