CAJ | 학술논문

目的探讨高低危型人乳头瘤病毒(human papilloma virus,HPV)在不同年龄段的感染情况,为防治宫颈癌、尖锐湿疣等HPV相关疾病提供理论依据.方法收集有HPV感染临床检测指征(宫颈炎、宫颈上皮内瘤变及宫颈癌)的女性标本901例,利用导流杂交基因芯片技术对阴道分泌物进行HPV分型检测.结果 901例标本HPV阳性率为41.73％,其中单纯高、低危型HPV和高低危型HPV混合感染率分别为60.90％ (229/376)、23.67％ (89/376)和15.43％(58/376)；高危型HPV感染各个年龄段的感染率为26.39％～42.19％,低危型HPV感染各个年龄段的感染率为8.96％～39.19％,各型均呈现“U”型趋势.结论各年龄段主要感染型别为HPV16.低年龄段以高低危型HPV混合感染为主,≥55岁以单纯高危型HPV感染为主,单纯高危型HPV感染率随年龄增长而上升.
목적 탐토고저위형인유두류병독(human papilloma virus,HPV)재불동년령단적감염정황,위방치궁경암、첨예습우등HPV상관질병제공이론의거.방법 수집유HPV감염림상검측지정(궁경염、궁경상피내류변급궁경암)적녀성표본901례,이용도류잡교기인심편기술대음도분비물진행HPV분형검측.결과 901례표본HPV양성솔위41.73％,기중단순고、저위형HPV화고저위형HPV혼합감염솔분별위60.90％ (229/376)、23.67％ (89/376)화15.43％(58/376)；고위형HPV감염각개년령단적감염솔위26.39％～42.19％,저위형HPV감염각개년령단적감염솔위8.96％～39.19％,각형균정현“U”형추세.결론 각년령단주요감염형별위HPV16.저년령단이고저위형HPV혼합감염위주,≥55세이단순고위형HPV감염위주,단순고위형HPV감염솔수년령증장이상승.
Objective To investigate the infection rate of high-risk and low-risk HPV in different age groups,and provide the theoretical foundation for preventing and treating the diseases caused by HPV,such as cervical cancer and condylomata acuminate.Methods Samples were collected from 901 female patients with clinical indication for testing.The flow-through hybridization and gene chip were used to identifiy the subtypes.Results 376 cases were infected with HPV (41.73％) among the 901 patients.The positive rates of only high-risk and low-risk types of HPV were 60.90％ and 23.67％ respectively.Positive rate of mixed infection with high and low-risk types HPV was 15.43％.The infection rates of high-risk type HPV in different age groups were from 26.39％ to 42.19％.The infection rates of low-risk type HPV in different age groups were from 8.96％ to 39.19％.Both the groups showed a "U" trend.Conclusions HPV16 infection is the dominant type in different age groups.Low age groups were mainly mixed infected with high and low-risk HPV.≥55 years group was mainly infected with simple high-risk HPV; simple high-risk HPV infection rates rise with age.