CAJ | 학술논문

目的研究新剂型重组人干扰素(interferon,IFN)α2b胶囊抗小鼠疱疹病毒性阴道炎的效果.方法人工建造阴道感染HSV-2的小鼠模型,以不同剂量的IFNα2b对小鼠阴道局部用药,以阿昔洛韦(acyclovir,ACV)为阳性对照.观察药物干扰对模型小鼠发病率、死亡率及病程进展的影响.结果试验药物能减少小鼠的病死数、发病数,减慢小鼠的病程进展,其中16000IU/天高剂量组效果最好,类似于ACV组的用药效果,4000IU/天的低剂量用药组效果最弱,8000IU/天中剂量组效果居中.结论受试药物在小鼠体内具有良好的抗HSV-2感染所致阴道炎的作用.
목적 연구신제형중조인간우소(interferon,IFN)α2b효낭항소서포진병독성음도염적효과.방법 인공건조음도감염HSV-2적소서모형,이불동제량적IFNα2b대소서음도국부용약,이아석락위(acyclovir,ACV)위양성대조.관찰약물간우대모형소서발병솔、사망솔급병정진전적영향.결과 시험약물능감소소서적병사수、발병수,감만소서적병정진전,기중16000IU/천고제량조효과최호,유사우ACV조적용약효과,4000IU/천적저제량용약조효과최약,8000IU/천중제량조효과거중.결론 수시약물재소서체내구유량호적항HSV-2감염소치음도염적작용.
Objective To observe the curative effect of recombinant human interferon (rhIFN) α2b capsule on vaginitis in mice caused by HSV-2.Methods Establish experimental mice model of vaginitis by HSV-2 infection,and treated through mice vaginal with experimental rhIFN α2b at different dosages,using acyclovir as drug control.The morbidity,mortality,and appearance progression of model mice were observed after drug interference.Results The experimental rhIFN α2b treatment can decrease the morbidity,mortality,and disease progression of model mice.The drug effect of high dose 16000IU/d,similar to ACV control,is the best.The effect of low-dose group with rhIFN α2b 4000IU/d treatment is the weakest,and that of mid-dose 8000IU/d is slightly better.Conclusions The tested drug rhIFNα2b showed significant curative effect on mice experimental vaginitis caused by HSV-2.