CAJ | 학술논문

目的探讨肿瘤患者化疗后出现乙肝病毒再活化的危险因素.方法选择携带乙肝病毒并需住院化疗的恶性肿瘤患者42例.化疗后根据乙肝病毒再活化情况,分成病例组和对照组,应用logistic回归分析出现乙肝病毒再活化的危险因素.结果化疗后42.85％的患者出现了乙肝病毒再活化.多因素非条件logistic回归分析发现,共有3个因素进入回归方程,其中患淋巴瘤(OR=1.5,95％CI 1.2-33.3)、乳腺癌(0R=1.9,95％CI 1.2-50.0)、使用蒽环类药物(OR=1.6,95％ CI1.4-6.7)为引起肿瘤患者乙肝病毒再活化危险因素.结论使蒽环类药物、患乳腺癌和淋巴瘤是导致乙肝病毒再活化的危险因素.
목적 탐토종류환자화료후출현을간병독재활화적위험인소.방법 선택휴대을간병독병수주원화료적악성종류환자42례.화료후근거을간병독재활화정황,분성병례조화대조조,응용logistic회귀분석출현을간병독재활화적위험인소.결과 화료후42.85％적환자출현료을간병독재활화.다인소비조건logistic회귀분석발현,공유3개인소진입회귀방정,기중환림파류(OR=1.5,95％CI 1.2-33.3)、유선암(0R=1.9,95％CI 1.2-50.0)、사용은배류약물(OR=1.6,95％ CI1.4-6.7)위인기종류환자을간병독재활화위험인소.결론 사은배류약물、환유선암화림파류시도치을간병독재활화적위험인소.
Objective To investigate the risk factors of chemotherapy-induced reactivation of hepatitis B virus in tumor patients.Methods A total of 42 patients with malignant tumor and carrying hepatitis B virus were collected when they treated in the Ninth People's Hospital of the Shenzhen.After giving several treatment cycle of chemotherapy,patients who developed reactivation of hepatitis B virus were assigned to the case group while patients who didn't suffer from this problem were assigned to control group.Logistic regression was used to analyze the risk factors of reactivation of hepatitis B virus after chemotherapy.Results The reactivation of hepatitis B virus was found in 18 patients,which accounted for 42.85％ of the total patients.By multiple logistic regression,we found that risk was risen by suffering breast cancer (OR =1.9,95％ CI1.2-50.0),lymphoma (OR =1.5,95 ％ CI 1.2-33.3) and treated by anthracyclines (OR =1.6,95 ％CI 1.4-6.7).Conclusions Suffering breast cancer,lymphoma and treated by anthracyclines are risk factors of reactivation of hepatitis B virus.