CAJ | 학술논문

HOXB基因是同源盒基因家族的成员之一,在造血调控中发挥重要的作用,其表达异常参与了白血病的发生,各亚型的差异性高表达影响白血病的进展及表型,还与白血病的治疗和预后密切相关,表达水平越高对治疗的反应越差,预后也较差.通过转基因、抑制P21、联合细胞因子或MS-5细胞株、全反式维甲酸等方法在基因水平进行研究,可为揭示白血病的发病机制及治疗和预后提供理论基础.
HOXB기인시동원합기인가족적성원지일,재조혈조공중발휘중요적작용,기표체이상삼여료백혈병적발생,각아형적차이성고표체영향백혈병적진전급표형,환여백혈병적치료화예후밀절상관,표체수평월고대치료적반응월차,예후야교차.통과전기인、억제P21、연합세포인자혹MS-5세포주、전반식유갑산등방법재기인수평진행연구,가위게시백혈병적발병궤제급치료화예후제공이론기출.
HOXB gene is a homeobox gene family member and plays an important role in hematopoietic regulation.The abnormal expression is involved in leukemia.High expression of different subtypes influence leukemia progress and phenotype,and are closely related with leukemia treatment and prognosis.The higher the expression level is,the worse prognosis is.Many methods such as transgenic,inhibit of P21,combined with cytokine or MS-5 cell lines( all-trans retinoic acid) at the genetic level can reveal the pathogenesis of leukemi a and provide theoretical basis for treatment and prognosis.