国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2013年
1期
35-37
,共3页
多囊卵巢综合征%产前雄激素%脂肪组织扩张%胰岛素抵抗
多囊卵巢綜閤徵%產前雄激素%脂肪組織擴張%胰島素牴抗
다낭란소종합정%산전웅격소%지방조직확장%이도소저항
Polycystic ovary syndrome%Prenatal androgen%Adipose tissue expandability%Insulin resistance
多囊卵巢综合征(polycystic ovary syndrome,PCOS)多起病于青春期,可能与早期生命活动有关.产前高雄激素可作用于胎儿宫内环境,参与成年后PCOS的发病.胎儿宫内生长受限,导致成年后胰岛素抵抗等病理生理改变,也是PCOS发生的潜在病因.该文就PCOS疾病胎源学说中的“产前雄激素过高”及“脂肪组织扩张受限学说”与PCOS的的关系进行综述.
多囊卵巢綜閤徵(polycystic ovary syndrome,PCOS)多起病于青春期,可能與早期生命活動有關.產前高雄激素可作用于胎兒宮內環境,參與成年後PCOS的髮病.胎兒宮內生長受限,導緻成年後胰島素牴抗等病理生理改變,也是PCOS髮生的潛在病因.該文就PCOS疾病胎源學說中的“產前雄激素過高”及“脂肪組織擴張受限學說”與PCOS的的關繫進行綜述.
다낭란소종합정(polycystic ovary syndrome,PCOS)다기병우청춘기,가능여조기생명활동유관.산전고웅격소가작용우태인궁내배경,삼여성년후PCOS적발병.태인궁내생장수한,도치성년후이도소저항등병리생리개변,야시PCOS발생적잠재병인.해문취PCOS질병태원학설중적“산전웅격소과고”급“지방조직확장수한학설”여PCOS적적관계진행종술.
The clinical manifestations of polycystic ovary syndrome(PCOS) often emerge during childhood and are related with early life events.Fetal androgen excess may contribute to the etiology of PCOS.Otherwise,fetal growth restriction can confer a setpoint of maximal adipose tissue expansion and may lead to a state of insulin resistance which may finally contribute to the pathophysiology of PCOS.Two hypothesis,the prenatal androgen hypothesis and the adipose tissue expandability hypothesis,have been advanced,and have explained the prenatal origins of PCOS.This paper discusses the relationship between the PCOS and the two hypotheses to demonstrate the PCOS as a "fetal origins of adult disease".
