CAJ | 학술논문

孕期充足的碘营养是胎儿神经发育的关键,在碘严重缺乏地区,母亲及胎儿低甲状腺素血症可导致呆小症,损害子代的认知发育,甚至轻度的缺乏都可损害子代的认知行为.世界卫生组织近来建议孕妇每日推荐的碘摄入量从200 μg/L提高至250μg/L,并认为孕妇尿碘平均浓度为150～249 μg/L表明碘摄入充足.对于孕期重度碘缺乏影响子代神经认知发育的相关报道及研究较多,但母亲轻度或中度碘缺乏是否对子代认知功能产生影响,目前尚不清楚.该文综述了孕期碘营养状况的评估及孕期不同程度碘缺乏对子代认知发育的影响,并提倡孕前或早期补碘,预防胎儿的神经行为发育损害.
잉기충족적전영양시태인신경발육적관건,재전엄중결핍지구,모친급태인저갑상선소혈증가도치태소증,손해자대적인지발육,심지경도적결핍도가손해자대적인지행위.세계위생조직근래건의잉부매일추천적전섭입량종200 μg/L제고지250μg/L,병인위잉부뇨전평균농도위150～249 μg/L표명전섭입충족.대우잉기중도전결핍영향자대신경인지발육적상관보도급연구교다,단모친경도혹중도전결핍시부대자대인지공능산생영향,목전상불청초.해문종술료잉기전영양상황적평고급잉기불동정도전결핍대자대인지발육적영향,병제창잉전혹조기보전,예방태인적신경행위발육손해.
Consuming an adequate amount of iodine during pregnancy is critical for fetal neurologic development.Even a mild deficiency can impair cognitive ability.The World Health Organization recently has increased their recommended iodine intake during pregnancy from 200 to 250 μg/d and suggested that a median urinary iodine concentration of 150 ～ 249 μg/L indicates adequate iodine intake in pregnant women.Whether mild-to-moderate maternal iodine deficiency produces more subtle changes in cognitive function in offspring is unclear;no controlled intervention studies have measured long-term clinical outcomes.This review summarizes the iodine nutrition of pregnant women,and the effects of iodine deficiency in pregnancy on neurodevelopment in the child.To prevent fetal damage,iodine should be given before or early in pregnancy.