国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2013年
2期
152-154
,共3页
胰岛素样生长因子1%胰岛素样生长因子结合蛋白3%生长激素%治疗
胰島素樣生長因子1%胰島素樣生長因子結閤蛋白3%生長激素%治療
이도소양생장인자1%이도소양생장인자결합단백3%생장격소%치료
Insulin like growth actor 1%Insulin like growth factor binding protein 3%Growth hormone%Treatment
基因重组人生长激素(recombinant human growth hormone,rhGH)已广泛应用于儿科临床治疗生长激素缺乏症,并已取得较满意的疗效.生长激素(growth hormone,GH)通过刺激肝脏细胞产生胰岛素样生长因子(insulin-like growth actor,IGF-1)来介导GH的促生长作用.血浆中大部分IGF-1与胰岛素样生长因子结合蛋白3结合,IGF-1具有促进细胞有丝分裂抑制细胞凋亡的作用,近年来发现IGF-1与肿瘤的发生发展有一定相关性,因而引发了对rhGH治疗的安全性和有效性的关注.
基因重組人生長激素(recombinant human growth hormone,rhGH)已廣汎應用于兒科臨床治療生長激素缺乏癥,併已取得較滿意的療效.生長激素(growth hormone,GH)通過刺激肝髒細胞產生胰島素樣生長因子(insulin-like growth actor,IGF-1)來介導GH的促生長作用.血漿中大部分IGF-1與胰島素樣生長因子結閤蛋白3結閤,IGF-1具有促進細胞有絲分裂抑製細胞凋亡的作用,近年來髮現IGF-1與腫瘤的髮生髮展有一定相關性,因而引髮瞭對rhGH治療的安全性和有效性的關註.
기인중조인생장격소(recombinant human growth hormone,rhGH)이엄범응용우인과림상치료생장격소결핍증,병이취득교만의적료효.생장격소(growth hormone,GH)통과자격간장세포산생이도소양생장인자(insulin-like growth actor,IGF-1)래개도GH적촉생장작용.혈장중대부분IGF-1여이도소양생장인자결합단백3결합,IGF-1구유촉진세포유사분렬억제세포조망적작용,근년래발현IGF-1여종류적발생발전유일정상관성,인이인발료대rhGH치료적안전성화유효성적관주.
Recombinant human growth hormone (rhGH) has been widely used in clinical treatment of growth hormone deficiency(GHD),and has achieved satisfactory effect.Growth hormone (GH) can stimulate liver cells to produce insulin-like growth actor(IGF-1) which mediated GH growth promoting effect.The majority of IGF-1 combine with insulin like growth factor binding protein 3.IGF-I promotes cell mitotic and inhibit cell apoptosis,in recent years,some scholars have reported that there is a certain relationship between IGF-1 and tumor occurrence and development,and thus leading to the attention to the efficacy and safety of rhGH treatment.
