CAJ | 학술논문

目的探讨维生素E(VitE)在防治早产儿贫血中的临床疗效.方法选择我院新生儿病房2010年12月至2011年12月收治的早产儿90例,按入住先后顺序随机分为对照组(A组)、VitE大剂量组(B组)、VitE小剂量组(C组).A组30例,人院后第7天起给予促红细胞生成素(EPO),每周750 IU/kg分3次皮下注射,共4周；同时加服铁剂每日6 mg/kg.另2组在上述对照治疗的基础上,加服不同剂量VitE,共4周.B组30例,VitE每日15 mg/kg；C组30例,VitE每日2.5mg/kg.观察治疗过程中各组血细胞压积(Hct)、血红蛋白(Hb)、红细胞(RBC)、网织红细胞(Ret)及其治疗前后血清VitE浓度的变化.结果治疗后B、C组患者Hct、Hb、RBC、Ret均有所改善,各项指标改善程度与A组比较,差异有统计学意义(P＜0.05),B与C组各项指标改善程度未见明显差异(P＞0.05).B、C组治疗后血清VitE浓度可见明显升高,且差异有统计学意义(P＜0.05),A组患者上升不明显.结论在EPO防治早产儿贫血的同时应加服小剂量VitE.
목적 탐토유생소E(VitE)재방치조산인빈혈중적림상료효.방법 선택아원신생인병방2010년12월지2011년12월수치적조산인90례,안입주선후순서수궤분위대조조(A조)、VitE대제량조(B조)、VitE소제량조(C조).A조30례,인원후제7천기급여촉홍세포생성소(EPO),매주750 IU/kg분3차피하주사,공4주；동시가복철제매일6 mg/kg.령2조재상술대조치료적기출상,가복불동제량VitE,공4주.B조30례,VitE매일15 mg/kg；C조30례,VitE매일2.5mg/kg.관찰치료과정중각조혈세포압적(Hct)、혈홍단백(Hb)、홍세포(RBC)、망직홍세포(Ret)급기치료전후혈청VitE농도적변화.결과 치료후B、C조환자Hct、Hb、RBC、Ret균유소개선,각항지표개선정도여A조비교,차이유통계학의의(P＜0.05),B여C조각항지표개선정도미견명현차이(P＞0.05).B、C조치료후혈청VitE농도가견명현승고,차차이유통계학의의(P＜0.05),A조환자상승불명현.결론 재EPO방치조산인빈혈적동시응가복소제량VitE.
Objective To research the therapeutic effect of vitamin E in prevention and treatment of anemia in premature children.Methods We investigated 90 cases of premature children admitted to the neonatal ward of our hospital from December 2010 to December 2011.According to hospital successively order these premature were randomly divided into control group (Group A),high-dose group (Group B),low-dose group (Group A).Group A including 30 cases,subcutaneous injection of erythropoietin(EPO) from the 7th days after admission,750IU/kg weekly for 3 times,for 4 weeks.At the same time,plus iron 6mg/(kg·d).On the basis of the above-mentioned control treatment,oral administration of different doses of vitamin E was in the treatment group,for 4 weeks.Group B including 30 cases was given vitamin E 15mg/(kg·d).Group C including 30 cases was given vitamin E 2.5mg/(kg· d).The changes of each group during the treatment in hematocrit (Hct),hemoglobin(Hb),red blood cell(RBC),reticulocyte(Ret) and the changes of serum concentrations of vitamin E before and after treatment were observed.Results Hct,Hb,RBC,Ret in group B,group C patients were both improved.The improvement of the indicators was better than that of group A (P ＜ 0.05).There was no significant difference between the improvement of each index of Group B and Group C(P ＞ 0.05).Serum concentrations of vitamin E after treatment in group B and group C patients were significantly higher and the difference was statistically significant(P ＜ 0.05).Serum concentration of vitamin E in group A didn't increase obviously.Conclusion Additional small doses of VitE should be given during EPO prevention of anemia in premature children.