CAJ | 학술논문

生物节律是生物界最普遍的生物钟节律,存在于几乎所有的生物体.在哺乳动物及人类,昼夜节律中枢位于下丘脑视交叉上核,在外周组织中也存在节律振荡器,二者通过神经体液联系整合,并与外界同步,对机体的各种生理活动和行为过程进行调控.生物钟的紊乱会造成糖耐量降低,胰岛素分泌异常,导致糖代谢异常.同时葡萄糖、光照、轮班、饮食等原因也可以引起对生物钟时相的移动而影响糖代谢.该文主要综述了生物钟基因对糖代谢的调控影响.
생물절률시생물계최보편적생물종절률,존재우궤호소유적생물체.재포유동물급인류,주야절률중추위우하구뇌시교차상핵,재외주조직중야존재절률진탕기,이자통과신경체액련계정합,병여외계동보,대궤체적각충생리활동화행위과정진행조공.생물종적문란회조성당내량강저,이도소분비이상,도치당대사이상.동시포도당、광조、륜반、음식등원인야가이인기대생물종시상적이동이영향당대사.해문주요종술료생물종기인대당대사적조공영향.
Circadian rhythm,as the most common biological rhythm of the biosphere,exists in almost all organisms.The circadian rhythm center of mammals and humans is in the suprachiasmatic nucleus of the hypothalamus and circadian oscillation is also found in peripheral organ.By the united integration of neurohumor and external synchronous,these two regulate various physiological activities and behavior processes of organisms.The disturbance of circadian clock causes impaired glucose tolerance and insulin secretory abnormalities,which further results in abnormal glucose metabolism.Another reason for impaired glucose metabolism is the movement of circadian clock phases caused by glucose,illumination,shift and diet.The review summarizes the clock genes'regulatory influence on saccharometabolism.