CAJ | 학술논문

目的探讨孕母妊娠期情况及新生儿出生时的生理及病理状况对脐带血凝血因子活性水平的影响.方法采用全自动凝血分析仪及其配套试剂检测新生儿脐带血中凝血因子水平活性水平,按影响因素分组进行统计学比较,分析脐带血凝血因子活性水平的影响因素.结果 (1)新生儿因素:正常男、女新生儿脐带血凝血因子水平的差异无统计学意义(P＞0.05)；早产儿凝血因子FⅡ、FⅤ、FⅨ和FⅨ/Ⅺ活性水平较足月儿低(P=0.031、0.037、0.000、0.002)；巨大儿FⅡ和FⅦ较出生体重正常组高(P =0.043、0.043)；剖宫分娩组的FⅧ较自然阴道分娩组低(P =0.004)；双胎妊娠组的FⅧ、FⅨ和FⅪ较单胎妊娠组低(P =0.002、0.000、0.028)；宫内缺氧组的FⅡ和FⅧ较无宫内缺氧组低(P =0.032、0.012).(2)孕母因素:高龄初产组的FⅡ和FⅨ活性水平均较适龄初产组高(P =0.009、0.028)；围生期感染组的FⅪ较围生期非感染组低(P =0.042)；妊娠合并糖尿病组与非妊娠合并糖尿病组比较,两组各凝血因子水平均无统计学意义(P＞0.05)；妊娠合并妇科疾病组的FⅧ较妊娠无合并妇科疾病组低(P =0.043),其FⅡ、Ⅶ、和FⅩ较高(P =0.032、0.024、0.022).结论早产、剖宫产、双胎、宫内缺氧、围生期感染等因素对脐带血FⅡ、FⅧ、FⅨ和FⅫ活性水平影响较大,为预防新生儿出血性疾病应避免上述因素.
목적 탐토잉모임신기정황급신생인출생시적생리급병리상황대제대혈응혈인자활성수평적영향.방법 채용전자동응혈분석의급기배투시제검측신생인제대혈중응혈인자수평활성수평,안영향인소분조진행통계학비교,분석제대혈응혈인자활성수평적영향인소.결과 (1)신생인인소:정상남、녀신생인제대혈응혈인자수평적차이무통계학의의(P＞0.05)；조산인응혈인자FⅡ、FⅤ、FⅨ화FⅨ/Ⅺ활성수평교족월인저(P=0.031、0.037、0.000、0.002)；거대인FⅡ화FⅦ교출생체중정상조고(P =0.043、0.043)；부궁분면조적FⅧ교자연음도분면조저(P =0.004)；쌍태임신조적FⅧ、FⅨ화FⅪ교단태임신조저(P =0.002、0.000、0.028)；궁내결양조적FⅡ화FⅧ교무궁내결양조저(P =0.032、0.012).(2)잉모인소:고령초산조적FⅡ화FⅨ활성수평균교괄령초산조고(P =0.009、0.028)；위생기감염조적FⅪ교위생기비감염조저(P =0.042)；임신합병당뇨병조여비임신합병당뇨병조비교,량조각응혈인자수평균무통계학의의(P＞0.05)；임신합병부과질병조적FⅧ교임신무합병부과질병조저(P =0.043),기FⅡ、Ⅶ、화FⅩ교고(P =0.032、0.024、0.022).결론 조산、부궁산、쌍태、궁내결양、위생기감염등인소대제대혈FⅡ、FⅧ、FⅨ화FⅫ활성수평영향교대,위예방신생인출혈성질병응피면상술인소.
Objective To investigate the influence on levels of coagulation factors in cord blood,included the physiological and pathological status of mater and the newborn.Methods We Detected the levels of F Ⅱ 、FⅤ 、FⅦ 、FⅧ 、FⅨ 、FⅩ 、FⅪ and FⅫ in cord blood by CA-1500 Automatic blood coagulation analyzer and related reagents,group results by impact factors and compared them statistically.Results (1) Factors of newborn:every coagulation factor between the male group and the female group was no statistical difference(P ＞0.05) ;F Ⅱ,F Ⅴ,FⅨ and FⅪ in the group of premature infant were less active than the normal (P =0.031,0.037,0.000,0.002) ;FⅡ and FⅦ in the group of birth weight ＞4.0 kg were more active than the normal (P =0.043,0.043) ; FⅧ in the group of cesarean section was less active than the normal (P =0.004) ; FⅧ,FⅨ and FⅪ in the group of twin pregnancy were less active than the normal (P =0.002,0.000,0.028) ;F Ⅱ and F Ⅷ in the group of intrauterine hypoxia were less active than the normal (P =0.032,0.012).(2) Factors of mater:F Ⅱ and FⅨ in the group of≥35-year-old mothers with first delivery were more active than the normal (P =0.009,0.028).Every coagulation factor between the gestational diabetes mellitus (GDM) group and the not GDM group was no statistical difference(P ＞0.05) ;FⅧ in the group of pregnancy associated with gynecologic diseases was less active than the normal (P =0.043),F Ⅱ,Ⅶ and F Ⅹ were more active than the normal (P =0.032,0.024,0.022).Conclusion Premature birth,cesarean,twins,intrauterine hypoxia,perinatal infection and other factors have greater impact on the levels of FⅡ,FⅧ,FⅨ and FⅪ in cord blood.To prevent hemorrhagic disease of the newborn,we should avoid the factors mentioned above.