CAJ | 학술논문

肠道微生态是由体内有益菌及有害菌共同构成的生态环境,是人体最大、最复杂的微生态系统.研究表明,适当的肠道微生物定植过程有助于肠道结构和功能发育以及免疫系统成熟,它决定了之后肠道发生疾病的风险.肠道微生态或益生菌与新生儿坏死性小肠结肠炎(neonatal necrotizing enterocolitis,NEC)的关系已越来越受到关注.该文就新生儿肠道微生态的构成及作用、肠道微生态在NEC发生中的作用及机制、益生菌对NEC的防治作用等研究进展作一综述.
장도미생태시유체내유익균급유해균공동구성적생태배경,시인체최대、최복잡적미생태계통.연구표명,괄당적장도미생물정식과정유조우장도결구화공능발육이급면역계통성숙,타결정료지후장도발생질병적풍험.장도미생태혹익생균여신생인배사성소장결장염(neonatal necrotizing enterocolitis,NEC)적관계이월래월수도관주.해문취신생인장도미생태적구성급작용、장도미생태재NEC발생중적작용급궤제、익생균대NEC적방치작용등연구진전작일종술.
The intestinal microbiota is composed of beneficial bacteria and harmful bacteria in the body as the ecological environment,which is the largest,most complex microecosystem.There is emerging evidence that appropriate colonization process of intestinal microbes contributes to development of intestinal structure and function and maturation of immune system,which determines the risk of intestinal diseases.More and more studies focus on the relationship between intestinal microecology or probiotics and neonatal necrotizing enterocolitis (NEC).This article reviews the composition and function of neonatal intestinal microbiota,the intestinal microflora in the pathogenesis and mechanism of NEC and preventive effects of probiotics on NEC.