CAJ | 학술논문

灰质异位症为神经元移行障碍的一种,可分为室管膜下型、皮层下型、板层型及混合型四种临床类型;发生于神经元移行期的各种理化及生物因素、遗传因素均可导致该症的产生.最新研究表明,基因异常在灰质异位症,尤其是室管膜下型灰质异位症及板层型灰质异位症的发生中,占有重要作用,且其表现有一定特异性.灰质异位症儿童期发病主要表现为发育落后、癫(痫)及运动障碍,其诊断主要依靠影像学检查,尤其是磁共振检查.磁共振新技术,如磁共振波谱分析、功能磁共振等可协助诊断该病.
회질이위증위신경원이행장애적일충,가분위실관막하형、피층하형、판층형급혼합형사충림상류형;발생우신경원이행기적각충이화급생물인소、유전인소균가도치해증적산생.최신연구표명,기인이상재회질이위증,우기시실관막하형회질이위증급판층형회질이위증적발생중,점유중요작용,차기표현유일정특이성.회질이위증인동기발병주요표현위발육락후、전(간)급운동장애,기진단주요의고영상학검사,우기시자공진검사.자공진신기술,여자공진파보분석、공능자공진등가협조진단해병.
Gray matter heterotopias,which can be classified into subependymal heterotopia,subcortical heterotopia,band heterotopia and mixed heterotopia,belongs to neuronal migration disorders.Any factors including physical or chemical factors,biological factors and genetical factors that occur during neuronal migration phase can lead to gray matter heterotopias.The latest studies have revealed many genes are involved in the pathogenesis of gray matter heterotopias,especially in subependymal heterotopia and band heterotopia with their own characteristics.The main clinical disorders in pediatric heterotopias include developmental delay,epilepsy and motor disturbance.The diagnosis of the disease is made through neuroimaging examinations especially magnetic resonance imagings.The advanced magnetic techniques like magnetic resonance spectroscopy and functional magnetic resonance can be helpful in the final diagnosis.