CAJ | 학술논문

目的通过检测先天性心脏病(congenital heart disease,CHD)患儿在行心脏手术前血浆中的氨基末端B型脑利钠肽前体(amino-terminal pro-B-type natriuretic peptide,NT-proBNP)血浆浓度,绘制ROC曲线分析其敏感度、特异度及约登指数,探讨0～5岁经年龄分层前后充血性心力衰竭(congestiveheart failure,CHF)患儿血浆NT-proBNP诊断界值.方法测定2011年1月至2013年1月收治的100例CHD术前患儿(试验组)及100例正常儿童(对照组)血浆NT-proBNP,合并CHF的CHD患儿(CHF组)经年龄分层又分为0～1岁组、～3岁组和～5岁组,探讨各自的NT-proBNP诊断CHF的界值.结果 100例CHD患儿中,34例符合改良Ross心力衰竭诊断标准,试验组在年龄分层前按照ROC曲线选取的NT-proBNP诊断CHF界值为502 ng/L,经年龄分层后0～1岁组、～3岁组、～5岁组的NT-proBNP诊断CHF界值分别为552 ng/L、449ng/L、349 ng/L.结论该研究结果显示,合并CHF的CHD术前患儿经年龄分层后0～1岁组、～3岁组、～5岁组的NT-proBNP诊断CHF界值分别为552 ng/L、449ng/L、349 ng/L.
목적 통과검측선천성심장병(congenital heart disease,CHD)환인재행심장수술전혈장중적안기말단B형뇌리납태전체(amino-terminal pro-B-type natriuretic peptide,NT-proBNP)혈장농도,회제ROC곡선분석기민감도、특이도급약등지수,탐토0～5세경년령분층전후충혈성심력쇠갈(congestiveheart failure,CHF)환인혈장NT-proBNP진단계치.방법 측정2011년1월지2013년1월수치적100례CHD술전환인(시험조)급100례정상인동(대조조)혈장NT-proBNP,합병CHF적CHD환인(CHF조)경년령분층우분위0～1세조、～3세조화～5세조,탐토각자적NT-proBNP진단CHF적계치.결과 100례CHD환인중,34례부합개량Ross심력쇠갈진단표준,시험조재년령분층전안조ROC곡선선취적NT-proBNP진단CHF계치위502 ng/L,경년령분층후0～1세조、～3세조、～5세조적NT-proBNP진단CHF계치분별위552 ng/L、449ng/L、349 ng/L.결론 해연구결과현시,합병CHF적CHD술전환인경년령분층후0～1세조、～3세조、～5세조적NT-proBNP진단CHF계치분별위552 ng/L、449ng/L、349 ng/L.
Objective To detect the plasma amino-terminal pro-B-type natriuretic peptide (NT-ProBNP) of children with congenital heart disease(CHD) prior to heart surgery,to analysize its sensitivity,specificity and Youden index by receiver operating characteristic(ROC) curve,to explore the cut-off values of plasma NTProBNP for the diagnosis of congestive heart failure(CHF) in children under 5 years old before and after age stratification.Method The plasma NT-proBNP was detected for 100 children with CHD prior to heart surgery (experimental group) and 100 normal children(control group) between January 2011 to January 2013.Age stratification(0 ～ 1 year group,～3 years group and ～ 5 year group) was conducted in children with CHF younger than 5 years old to explore the cut-off values of plasma NT-ProBNP for the diagnosis of CHF.Results The NT-proBNP of 34 patients with CHF(n =100) was in accordance to Ross criteria The cut-off values were 502 ng/ L before age stratification,and they were 552 ng/L,449 ng/L,349 ng/L after age stratification for 0 ～ 1 year group,～ 3 years group and ～ 5 group.Conclusion The cut-off values of plasma NT-ProBNP for CHF were 552 ng/L、449 ng/L、349 ng/L for 0 ～ 1 year group,～ 3 years group and ～ 5 year group.