CAJ | 학술논문

先天性心脏病是由于胚胎期心脏发育异常所致.心脏发育生物学研究发现,在心脏形态发育中,不同的细胞需经过严格的调控才能保证正确的定位和发育.心脏发育中,转录因子对基因表达的调控起到了重要作用.锌指转录因子GATA-6属胚胎发育过程中心脏细胞的早期标志之一,是参与先天性心脏病发病中的主要候选基因之一.GATA-6基因突变导致基因产物的转录活性改变,并与其他相关因子在先天性心脏病的发生中共同发挥作用.
선천성심장병시유우배태기심장발육이상소치.심장발육생물학연구발현,재심장형태발육중,불동적세포수경과엄격적조공재능보증정학적정위화발육.심장발육중,전록인자대기인표체적조공기도료중요작용.자지전록인자GATA-6속배태발육과정중심장세포적조기표지지일,시삼여선천성심장병발병중적주요후선기인지일.GATA-6기인돌변도치기인산물적전록활성개변,병여기타상관인자재선천성심장병적발생중공동발휘작용.
Congenital heart disease is caused by abnormal embryonic heart development.According to the research findings of developmental biology,different heart cells must be strictly regulated to ensure proper cell location and development.In the process of heart development,transcription factors play an important role in the regulation of gene expression.Zinc finger transcription factor GATA-6,an early indicator of myocardial cell development,is currently regarded as main candidate gene involved in the pathogenesis of congenital heart disease.GATA-6 gene mutations lead to changes in transcriptional activity of the gene product,which together with other relevant factors may play a role in the pathogenesis of congenital heart disease.