CAJ | 학술논문

近年来有研究报道miR-145是血管平滑肌表型调节过程中的关键因子,而表型调节过程是多种血管性疾病的共同病理过程.肾脏是血管富集器官,正常的血管功能对维持肾脏整体功能意义重大,但目前并无相关文章论述miR-145与肾脏血管之间相互作用机制.该文针对miR-145在血管平滑肌细胞表型调节中的可能作用机制进行论述,以期提高对miR145在肾脏血管相关问题中的认识.
근년래유연구보도miR-145시혈관평활기표형조절과정중적관건인자,이표형조절과정시다충혈관성질병적공동병리과정.신장시혈관부집기관,정상적혈관공능대유지신장정체공능의의중대,단목전병무상관문장논술miR-145여신장혈관지간상호작용궤제.해문침대miR-145재혈관평활기세포표형조절중적가능작용궤제진행논술,이기제고대miR145재신장혈관상관문제중적인식.
In recent years,miR-145 is frequently reported as a key regulator of the phenotypic switch in vascular smooth muscle cells(VSMC),while the switch is the common pathological progress in many kinds of vascular diseases.Kidney is rich of vessels,and the regular function of its vessels has significance in the integral function of kidney.But,there is no article discussing about the relationship between miR-145 and kidney until now.This paper mainly discusses the possible mechanism of miR-145 in VSMC and present feasible experimental methods in a bid to provide a new perspective on kidney and related matters.