国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
3期
316-318
,共3页
耐药性%细菌%新生儿重症监护病房
耐藥性%細菌%新生兒重癥鑑護病房
내약성%세균%신생인중증감호병방
Drug-resistance%Bacteria%Neonatal intensive care unit
目的 研究新生儿重症监护病房细菌感染的种类分布及其耐药情况.方法 对2011年11月至2013年11月于鞍山市中心医院NICU住院的903例患儿的各类送检标本细菌培养和药敏试验结果进行回顾性分析.采用K-B纸片扩散法对我院临床分离的病原菌进行药物敏感试验.结果 310份标本培养共分离病原菌73株,总阳性率为23.5％.革兰阴性菌37株,最常见的是大肠埃希菌,阳性远高于肺炎克雷白杆菌和铜绿假单胞菌;革兰阳性菌32株,最常见的是金黄色葡萄球菌,其次为表皮葡萄球菌;真菌4株,最常见是白色假丝酵母菌.这些病原菌对β-内酰胺类抗生素均产生不同程度的耐药.未发现对碳青霉烯类药物耐药的菌株.未发现对万古霉素耐药的革兰阳性菌株.表皮葡萄球菌的耐药情况要比金黄色葡萄球菌严重.结论大肠埃希菌、金黄色葡萄球菌、表皮葡萄球菌是我院NICU中检出率最高的病原菌,耐药性较严重.定期进行细菌耐药性监测,及时了解细菌耐药变迁,有助于减少细菌耐药,为临床经验用药提供依据.
目的 研究新生兒重癥鑑護病房細菌感染的種類分佈及其耐藥情況.方法 對2011年11月至2013年11月于鞍山市中心醫院NICU住院的903例患兒的各類送檢標本細菌培養和藥敏試驗結果進行迴顧性分析.採用K-B紙片擴散法對我院臨床分離的病原菌進行藥物敏感試驗.結果 310份標本培養共分離病原菌73株,總暘性率為23.5％.革蘭陰性菌37株,最常見的是大腸埃希菌,暘性遠高于肺炎剋雷白桿菌和銅綠假單胞菌;革蘭暘性菌32株,最常見的是金黃色葡萄毬菌,其次為錶皮葡萄毬菌;真菌4株,最常見是白色假絲酵母菌.這些病原菌對β-內酰胺類抗生素均產生不同程度的耐藥.未髮現對碳青黴烯類藥物耐藥的菌株.未髮現對萬古黴素耐藥的革蘭暘性菌株.錶皮葡萄毬菌的耐藥情況要比金黃色葡萄毬菌嚴重.結論大腸埃希菌、金黃色葡萄毬菌、錶皮葡萄毬菌是我院NICU中檢齣率最高的病原菌,耐藥性較嚴重.定期進行細菌耐藥性鑑測,及時瞭解細菌耐藥變遷,有助于減少細菌耐藥,為臨床經驗用藥提供依據.
목적 연구신생인중증감호병방세균감염적충류분포급기내약정황.방법 대2011년11월지2013년11월우안산시중심의원NICU주원적903례환인적각류송검표본세균배양화약민시험결과진행회고성분석.채용K-B지편확산법대아원림상분리적병원균진행약물민감시험.결과 310빈표본배양공분리병원균73주,총양성솔위23.5％.혁란음성균37주,최상견적시대장애희균,양성원고우폐염극뢰백간균화동록가단포균;혁란양성균32주,최상견적시금황색포도구균,기차위표피포도구균;진균4주,최상견시백색가사효모균.저사병원균대β-내선알류항생소균산생불동정도적내약.미발현대탄청매희류약물내약적균주.미발현대만고매소내약적혁란양성균주.표피포도구균적내약정황요비금황색포도구균엄중.결론대장애희균、금황색포도구균、표피포도구균시아원NICU중검출솔최고적병원균,내약성교엄중.정기진행세균내약성감측,급시료해세균내약변천,유조우감소세균내약,위림상경험용약제공의거.
Objective To investigate bacterial distribution and antibiotic resistance pattern in NICU of Central Hospital of Anshan,Liaoning province of China.Methods We conducted a retrospective analysis of all the cases admitted to the neonatal intensive care unit(NICU) between November 2011 and November 2013.Culture and sensitivity data of organisms isolated were documented as well.Antimicrobial susceptibility of the isolated pathogens was determined with the use of the Kirby-Bauer disk-diffusion test.Results A total of 73 bacterial strains were isolated from 310 specimens with a 23.5％ positive rate.In total,37 Gram-negative strains were detected and Escherichia coli was the predominant infective organism,far more common than Klebsiella pneumoniae and Pseudomonas aeruginosa.Gram-positive organisms were isolated in 32 cases and the most common pathogen was Staphylococcus aureus,followed by Staphylococcus epidermidis.Fungal isolates were recovered in 4 cases and Candida albicans was the most frequently isolated fungal organism.Carbapenem-resistant was not encountered and Vancomycin-resistant Staphylococcus aureus was not detected.Staphylococcus epidermidis isolates were significantly more resistant than Staphylococcus aureus.Conclusion Escherichia colis,Staphylococcus aureus and Staphylococcus epidermidis were the major pathogens in NICU of our hospital,showing a steep increase in antibiotic resistance.Regular monitoring and rational evaluation of drug resistance may help reduce the spread of antibiotic resistance,and provide the basis for empirical antimicrobial use.
