国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
3期
331-333,336
,共4页
急性肾损伤%细胞周期%细胞周期调控蛋白%细胞周期检测点
急性腎損傷%細胞週期%細胞週期調控蛋白%細胞週期檢測點
급성신손상%세포주기%세포주기조공단백%세포주기검측점
Acute kidney injury%Cell cycle%Cell cycle regulatory protein%Cell cycle checkpoint
急性肾损伤是临床常见的危重症,病死率高.急性肾损伤导致的细胞增生、肥大或凋亡与细胞周期调控有关,其中细胞周期G1/S检测点和G2/M检测点是急性肾损伤细胞周期的关键调控靶点,而细胞周期调控蛋白在其中起着关键性作用.但其确切调控机制尚不清楚,该文就急性肾损伤细胞周期调控机制进行简要概述.
急性腎損傷是臨床常見的危重癥,病死率高.急性腎損傷導緻的細胞增生、肥大或凋亡與細胞週期調控有關,其中細胞週期G1/S檢測點和G2/M檢測點是急性腎損傷細胞週期的關鍵調控靶點,而細胞週期調控蛋白在其中起著關鍵性作用.但其確切調控機製尚不清楚,該文就急性腎損傷細胞週期調控機製進行簡要概述.
급성신손상시림상상견적위중증,병사솔고.급성신손상도치적세포증생、비대혹조망여세포주기조공유관,기중세포주기G1/S검측점화G2/M검측점시급성신손상세포주기적관건조공파점,이세포주기조공단백재기중기착관건성작용.단기학절조공궤제상불청초,해문취급성신손상세포주기조공궤제진행간요개술.
Acute kidney injury(AKI) has emerged as a major public health problem that leads to decreased survival.In AKI,cell hyperplasia,hypertrophy and apoptosis are related to the cell cycle control.Two supervisory restriction points,G1/S and G2/M checkpoints,are responsible for cell-cycle control.Furthermore,cell cycle regulatory proteins are also involved in the regulation of the cell cycle in AKI.This review focuses on the cell cycle regulation mechanism of AKI.
