CAJ | 학술논문

p53基因一直是肿瘤病因学、放射生物学的研究热点,但受其调控的能量代谢在辐射生物效应中的作用还存在许多未知因素.了解p53基因调控的能量代谢对探讨肿瘤放射治疗疗效、辐射损伤、辐射致癌的早期筛选生物指标和分子流行病学调查均有着极其重要的意义.该文概述了此方面的研究进展.
p53기인일직시종류병인학、방사생물학적연구열점,단수기조공적능량대사재복사생물효응중적작용환존재허다미지인소.료해p53기인조공적능량대사대탐토종류방사치료료효、복사손상、복사치암적조기사선생물지표화분자류행병학조사균유착겁기중요적의의.해문개술료차방면적연구진전.
p53 is a hot spot in the studies of tumor etiology and radiobiology,but the function of p53-reguated energy metabolism in radiation biological effects still remains many uncertainties.The in-depth study of p53-regulated energy metabolism is of great significance to investigate the tumor radiotherapy efficacy,radiation damage,carcinogenesis and even molecular epidemiology.The current research progress at this point was stated in this article.