国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2013年
2期
77-80
,共4页
格雷夫斯病%Graves眼病%促甲状腺激素受体抗体
格雷伕斯病%Graves眼病%促甲狀腺激素受體抗體
격뢰부사병%Graves안병%촉갑상선격소수체항체
Graves disease%Graves ophthalmopathy%Thyrotrophin receptor antibody
目的 探讨血清促甲状腺激素受体抗体(TRAb)在Graves眼病发病机制中的作用.方法 选择初发Graves病患者219例,其中,Graves眼病组121例,无Graves眼病组98例,血清检测甲状腺功能、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)和TRAb水平,并根据欧洲Graves眼病专家组共识进行Graves眼病临床活动性评分(CAS)和严重程度评估.结果 Graves眼病组和非Graves眼病组的血清游离三碘甲状腺原氨酸、游离甲状腺素、TPOAb、TgAb和TRAb水平差异均无统计学意义,TRAb水平与Graves眼病病情的严重程度和CAS之间无相关关系.结论 Graves眼病患者的CAS和病情的严重程度与TRAb水平之间不存在相关关系,因此,TRAb水平与Graves眼病的关系还需要进一步研究.
目的 探討血清促甲狀腺激素受體抗體(TRAb)在Graves眼病髮病機製中的作用.方法 選擇初髮Graves病患者219例,其中,Graves眼病組121例,無Graves眼病組98例,血清檢測甲狀腺功能、甲狀腺過氧化物酶抗體(TPOAb)、甲狀腺毬蛋白抗體(TgAb)和TRAb水平,併根據歐洲Graves眼病專傢組共識進行Graves眼病臨床活動性評分(CAS)和嚴重程度評估.結果 Graves眼病組和非Graves眼病組的血清遊離三碘甲狀腺原氨痠、遊離甲狀腺素、TPOAb、TgAb和TRAb水平差異均無統計學意義,TRAb水平與Graves眼病病情的嚴重程度和CAS之間無相關關繫.結論 Graves眼病患者的CAS和病情的嚴重程度與TRAb水平之間不存在相關關繫,因此,TRAb水平與Graves眼病的關繫還需要進一步研究.
목적 탐토혈청촉갑상선격소수체항체(TRAb)재Graves안병발병궤제중적작용.방법 선택초발Graves병환자219례,기중,Graves안병조121례,무Graves안병조98례,혈청검측갑상선공능、갑상선과양화물매항체(TPOAb)、갑상선구단백항체(TgAb)화TRAb수평,병근거구주Graves안병전가조공식진행Graves안병림상활동성평분(CAS)화엄중정도평고.결과 Graves안병조화비Graves안병조적혈청유리삼전갑상선원안산、유리갑상선소、TPOAb、TgAb화TRAb수평차이균무통계학의의,TRAb수평여Graves안병병정적엄중정도화CAS지간무상관관계.결론 Graves안병환자적CAS화병정적엄중정도여TRAb수평지간불존재상관관계,인차,TRAb수평여Graves안병적관계환수요진일보연구.
Objective To explore the value of serum thyrotrophin receptor antibody (TRAb) on the pathological mechanism of Graves ophthalmopathy.Methods Two hundred and nineteen newly diagnosed Graves disease patients who were divided into Graves ophthalmopathy group (n=121) and without Graves ophthalmolpathy group (n=98) were tested serum concentration with thyroid function,thyroperoxidase antibodies (TPOAb),thyroglobulin antibodies (TgAb) and TRAb.According to the consensus statement of the European Group on Graves ophthalmopathy,clinical activity score (CAS)and severity evaluation were carried out on Graves ophthalmopathy patients.Results There was no significant difference in serum concentration of free thyroxine (FT4),free triiodothyronine (FT3),TPOAb and TRAb between the Graves ophthalmopathy group and the without Graves ophthalmopathy group.Serum concentration of TRAb was not correlated with the severity and CAS of Graves ophthalmopathy.Conclusions The CAS and the severity of Graves ophthalmopathy were irrelevant to the serum concentration of TRAb.Therefore,the correlation between TRAb and Graves ophthalmopathy still needs further study.
