CAJ | 학술논문

目的研究肺癌患者体重、血糖浓度和病灶大小对18F-FDG PET/CT病灶SUV的影响.方法 50例无糖尿病病史的肺癌患者中,21例有纵隔转移灶.所有患者均行常规18F-FDG PET/CT,使用Advantage Workstation图像处理工作站自动提取肺癌病灶SUV以及经过体重和体型校正的SUV.采用半自动方法提取肝脏参考本底SUV.肺癌原发灶和转移灶诊断参考标准按照肝脏参考本底SUV或体型校正SUV×1.5+2×标准差.结果 50例肺癌患者血糖浓度与肝脏参考本底SUV之间呈正相关,与肺癌原发灶SUV呈负相关,但是与转移灶SUV之间却呈正相关.按照参考诊断标准,50个肺癌原发灶和21个肺癌转移灶经过血糖浓度、病灶大小进行校正前和校正后,临床诊断的准确率分别为90.00％、71.43％和100％、95.24％.结论患者体重、血糖浓度和病灶大小对肺癌临床诊断准确率具有显著影响.经过血糖浓度、病灶大小校正后临床对肺癌诊断的准确率明显提高.这些结果提示,行18F-FDG PET/CT诊断肺癌时,需要高度重视患者体重、血糖浓度和病灶大小对结果的影响.
목적 연구폐암환자체중、혈당농도화병조대소대18F-FDG PET/CT병조SUV적영향.방법 50례무당뇨병병사적폐암환자중,21례유종격전이조.소유환자균행상규18F-FDG PET/CT,사용Advantage Workstation도상처리공작참자동제취폐암병조SUV이급경과체중화체형교정적SUV.채용반자동방법제취간장삼고본저SUV.폐암원발조화전이조진단삼고표준안조간장삼고본저SUV혹체형교정SUV×1.5+2×표준차.결과 50례폐암환자혈당농도여간장삼고본저SUV지간정정상관,여폐암원발조SUV정부상관,단시여전이조SUV지간각정정상관.안조삼고진단표준,50개폐암원발조화21개폐암전이조경과혈당농도、병조대소진행교정전화교정후,림상진단적준학솔분별위90.00％、71.43％화100％、95.24％.결론 환자체중、혈당농도화병조대소대폐암림상진단준학솔구유현저영향.경과혈당농도、병조대소교정후림상대폐암진단적준학솔명현제고.저사결과제시,행18F-FDG PET/CT진단폐암시,수요고도중시환자체중、혈당농도화병조대소대결과적영향.
Objective To study the effects of lung cancer patients' weight,blood glucose concentration and lesion size of lung cancer on 18F-FDG PET/CT lesions SUV results.Methods Fifty cases of lung cancer patients without a history of diabetes mellitus were enrolled in this study.Among them,21 patients with mediastinal metastases were detected.According to clinical routine 18F-FDG PET/CT scanning,automatic extraction of lung cancer SUV,weight and size correction SUV were obtained using the GE Advantage Workstation image processing workstation.Liver reference background SUV was obtained using semiautomatic extraction method of extraction.Lung cancer primary tumors and metastatic lesions diagnosis reference standards were accordant with the liver reference background SUV or SUV shape correction×1.5+2×standard deviation.Results Fifty cases of lung cancer in patients with blood sugar concentration and liver reference background SUV had positive correlation with lung cancer,SUV of primary lung cancer was negatively correlated with blood sugar,but it showed a positive correlation between blood sugar and lung metastases.According to the reference criteria for the diagnosis of 50 primary lung cancer cases and 21 metastatic lung cancer cases before and after the clinical diagnosis,the glucose concentration,lesion size correction accuracies were 90.00％,71.43％ and 100％,95.24％ respectively.Conclusions Patients' body weight,blood glucose concentration and lesion size significantly affect the accuracy of clinical diagnosis of lung cancer.After correction accuracy,it remarkably improved the clinical diagnosis of lung cancer.The results suggest that when using 18F-FDG PET/CT for lung cancer diagnosis,the effects of body weight,blood glucose concentration and lesion size should be concerned.