国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2013年
4期
216-220
,共5页
林美福%陈文新%周硕%郭莘%陈彩龙%陈国宝%戴红峰
林美福%陳文新%週碩%郭莘%陳綵龍%陳國寶%戴紅峰
림미복%진문신%주석%곽신%진채룡%진국보%대홍봉
受体,雌激素%乳腺肿瘤%雌二醇%氟脱氧葡萄糖F18%正电子发射断层显像术%体层摄影术,X线计算机
受體,雌激素%乳腺腫瘤%雌二醇%氟脫氧葡萄糖F18%正電子髮射斷層顯像術%體層攝影術,X線計算機
수체,자격소%유선종류%자이순%불탈양포도당F18%정전자발사단층현상술%체층섭영술,X선계산궤
Receptors,estrogen%Breast neoplasms%Estradiol%Fluorodeoxyglucose F18%Positronemission tomography%Tomography,X-ray computed
目的 探讨16α-[18F]氟-17β-雌二醇(18F-FES)PET/CT显像在乳腺癌诊疗中的应用价值.方法 对19例乳腺癌术前患者、7例乳腺癌术后转移患者行18F-FDG、18F-FES PET双显像剂显像,并与雌激素受体(ER)的表达情况进行对照分析.结果 19例乳腺癌术前患者中,乳腺癌原发灶ER阳性者9例,共10个病灶,18F-FES最大标准化摄取值(SUVmax)为3.45±2.34,与病灶的ER表达水平及病灶大小均密切相关；ER阴性者10例,共11个病灶,18F-FES SUVmax为0.74±0.12,两组间差异有统计学意义(t=3.782,P＜0.01).而ER阳性者和阴性者的18F-FDGSUVmax与病灶的ER表达水平无关.18F-FES PET/CT诊断原发灶ER阳性的灵敏度、特异度、准确率分别为100％、90.90％、95.23％.在7例术后转移患者中,原发灶ER阳性者3例,18F-FES共发现64个转移灶,而18F-FDG仅发现47个.结论 18F-FES PET/CT在ER阳性乳腺癌的特异性诊断、个性化治疗方案制定、疗效观察中具有非常重要的临床意义.
目的 探討16α-[18F]氟-17β-雌二醇(18F-FES)PET/CT顯像在乳腺癌診療中的應用價值.方法 對19例乳腺癌術前患者、7例乳腺癌術後轉移患者行18F-FDG、18F-FES PET雙顯像劑顯像,併與雌激素受體(ER)的錶達情況進行對照分析.結果 19例乳腺癌術前患者中,乳腺癌原髮竈ER暘性者9例,共10箇病竈,18F-FES最大標準化攝取值(SUVmax)為3.45±2.34,與病竈的ER錶達水平及病竈大小均密切相關；ER陰性者10例,共11箇病竈,18F-FES SUVmax為0.74±0.12,兩組間差異有統計學意義(t=3.782,P＜0.01).而ER暘性者和陰性者的18F-FDGSUVmax與病竈的ER錶達水平無關.18F-FES PET/CT診斷原髮竈ER暘性的靈敏度、特異度、準確率分彆為100％、90.90％、95.23％.在7例術後轉移患者中,原髮竈ER暘性者3例,18F-FES共髮現64箇轉移竈,而18F-FDG僅髮現47箇.結論 18F-FES PET/CT在ER暘性乳腺癌的特異性診斷、箇性化治療方案製定、療效觀察中具有非常重要的臨床意義.
목적 탐토16α-[18F]불-17β-자이순(18F-FES)PET/CT현상재유선암진료중적응용개치.방법 대19례유선암술전환자、7례유선암술후전이환자행18F-FDG、18F-FES PET쌍현상제현상,병여자격소수체(ER)적표체정황진행대조분석.결과 19례유선암술전환자중,유선암원발조ER양성자9례,공10개병조,18F-FES최대표준화섭취치(SUVmax)위3.45±2.34,여병조적ER표체수평급병조대소균밀절상관；ER음성자10례,공11개병조,18F-FES SUVmax위0.74±0.12,량조간차이유통계학의의(t=3.782,P＜0.01).이ER양성자화음성자적18F-FDGSUVmax여병조적ER표체수평무관.18F-FES PET/CT진단원발조ER양성적령민도、특이도、준학솔분별위100％、90.90％、95.23％.재7례술후전이환자중,원발조ER양성자3례,18F-FES공발현64개전이조,이18F-FDG부발현47개.결론 18F-FES PET/CT재ER양성유선암적특이성진단、개성화치료방안제정、료효관찰중구유비상중요적림상의의.
Objective To evaluate the role of 16α-[18F]fluoro-17β-oestradiol(18F-FES)PET/CT in the diagnosis and management of breast cancer.Methods Nineteen pre-operation cases with breast cancer and 7 post-operation cases with metastatic breast cancer underwent 18F-FES PET/CT and 18F-FDG PET/CT,and comparative analysis with the expression of estrogen receptor (ER)was performed.Results Of the primary lesions,the ER was positive in 9 patients (10 lesions),negative in 10 patients (11 lesions).The maximum standardized uptake value (SUVmax) for FES uptake was positively related to the lesion size and ER expression.The mean SUVmax for FES uptake was 3.45±2.34 in the 10 ER positive tumors,and 0.74±0.12 in the 11 ER negative tumors,which showed significant differences between the two groups (t=3.782,P＜0.01).The sensitivity,specificity and accuracy of FES PET for diagnosis ER positive patients were 100％,90.90％ and 95.23％ respectively.Sixty-four 18F-FES positive metastases were found in the three ER positive metastatic patients,whereas only 47 18F-FDG positive metastases were found.Conclusion 18F-FES PET/CT will be useful for diagnosis,individualized medicine and detecting therapeutic changes in patients with ER positive breast cancer.
