CAJ | 학술논문

Toll样受体4(TLR4)是一类重要的模式识别受体,不但广泛表达于免疫细胞,也表达于各种肿瘤细胞.TLR4通过不同的信号转导机制促进肿瘤的发生、发展、免疫逃逸、凋亡抵抗、转移和侵袭.激活的TLR4在肿瘤微环境中起着重要作用,且高表达的TLR4影响着肿瘤细胞的放射敏感性,进而严重影响肿瘤放疗的效果,对这些机制的研究可以进一步明确放疗的作用靶点,为恶性肿瘤的治疗提供新的手段.
Toll양수체4(TLR4)시일류중요적모식식별수체,불단엄범표체우면역세포,야표체우각충종류세포.TLR4통과불동적신호전도궤제촉진종류적발생、발전、면역도일、조망저항、전이화침습.격활적TLR4재종류미배경중기착중요작용,차고표체적TLR4영향착종류세포적방사민감성,진이엄중영향종류방료적효과,대저사궤제적연구가이진일보명학방료적작용파점,위악성종류적치료제공신적수단.
Toll-like receptor 4 (TLR4) is an important group of pattern recognition receptors,which is expressed not only on immune cells widely,but also on a variety of tumor cells.TLR4 can promote the development and progression,immune escape,apoptosis resistance,metastasis and invasion of tumors through different signal transduction mechanisms.Activated TLR4 plays an important role in the tumor microenvironment,and its influence on the radiosensitivity of tumor cells reduces the effect of radiation therapy severely.The study of these mechanisms can further identify the target for cancer radiotherapy,which will undoubtedly provide a new method for the treatment of malignant tumor.