CAJ | 학술논문

目的研究鼻咽癌在适形放疗(CRT)和调强放疗(IMRT)不同模式放疗后1周18F-FDG PET/CT显像早期评估的价值.方法对CRT组21例及IMRT组19例患者放疗后1周进行PET/CT显像评估,分别进行目测分析及测量最大标准化摄取值(SUVmax),并与两年临床随访结果及病理活检结果进行对照.结果 CRT组患者2年临床随访无肿瘤残留,IMRT组17例患者活检结果无残留、2例活检结果为阳性;放疗前PET/CT显像CRT组与IMRT组的SUVmax分别为9.57±4.33、9.40±3.32,两组间差异无统计学意义(t=-0.43,P=0.132);放疗后CRT组与IMRT活检阴性组的SUVmax分别为2.38±0.34、3.10±0.55,两组间差异有统计学意义(t=-3.4,P=0.002).CRT组目测诊断准确率为76.2％,目测假阳性率为23.8％;IMRT组目测诊断准确率为63.2％,目测假阳性率为36.8％.结论放疗后1周作为18F-FDG PET/CT对鼻咽癌CRT后评估时间点是可行的;放疗后1周IMRT组的SUVmax较高,不是PET/CT的最佳评估时间点.
목적 연구비인암재괄형방료(CRT)화조강방료(IMRT)불동모식방료후1주18F-FDG PET/CT현상조기평고적개치.방법 대CRT조21례급IMRT조19례환자방료후1주진행PET/CT현상평고,분별진행목측분석급측량최대표준화섭취치(SUVmax),병여량년림상수방결과급병리활검결과진행대조.결과 CRT조환자2년림상수방무종류잔류,IMRT조17례환자활검결과무잔류、2례활검결과위양성;방료전PET/CT현상CRT조여IMRT조적SUVmax분별위9.57±4.33、9.40±3.32,량조간차이무통계학의의(t=-0.43,P=0.132);방료후CRT조여IMRT활검음성조적SUVmax분별위2.38±0.34、3.10±0.55,량조간차이유통계학의의(t=-3.4,P=0.002).CRT조목측진단준학솔위76.2％,목측가양성솔위23.8％;IMRT조목측진단준학솔위63.2％,목측가양성솔위36.8％.결론 방료후1주작위18F-FDG PET/CT대비인암CRT후평고시간점시가행적;방료후1주IMRT조적SUVmax교고,불시PET/CT적최가평고시간점.
Objective To study the early evaluation value of 18F-FDG PET/CT imaging in nasopharyngeal carcinoma on the 7-day after different models of radiotherapy,including conformal radiotherapy(CRT) and intensity-modulated radiotherapy(IMRT).Methods PET/CT imaging was performed in 21 cases of CRT group and 19 cases of IMRT group on the 7-day after radiotherapy.The visual examination was performed and the maximum standardized uptake value (SUVmax) was measured,and the results were compared with the two years clinical follow-up and the result of pathological biopsy.Results Two years clinical follow-up of the CRT group confirmed there was no residual tumor.There was no residual tumor in 17 cases and 2 cases were positive of the IMRT group confirmed by biopsy.The SUVmax of the CRT group and the IMRT group were 9.57±4.33 and 9.40±3.32 respectively before radiotherapy without significant difference(t=-0.43,P=0.132).SUVmax of the CRT group and the negative patients confirmed by biopsy of the IMRT group were 2.38±0.34 and 3.1 ±0.55 respectively after radiotherapy with significant difference (t=-3.4,P=0.002).The accuracy rate and the false positive rate of visual examination of the CRT group were 76.2％ and 23.8％ respectively.The accuracy rate and the false positive rate of visual examination of the IMRT group were 63.2％ and 36.8％ respectively.Conclusions One week after nasopharyngeal carcinoma CRT is the feasible time-point for 18F-FDG PET/CT assessment.SUVmax of the IMRT group on 7-day after radiotherapy was higher than that in CRT group,so this time-point is not the best evaluation timepoint of the PET/CT.