国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2014年
4期
232-234,265
,共4页
心力衰竭,充血性%肌钙蛋白Ⅰ%C反应蛋白质%血浆N氨基末端脑钠肽前体%放射免疫测定%荧光免疫测定
心力衰竭,充血性%肌鈣蛋白Ⅰ%C反應蛋白質%血漿N氨基末耑腦鈉肽前體%放射免疫測定%熒光免疫測定
심력쇠갈,충혈성%기개단백Ⅰ%C반응단백질%혈장N안기말단뇌납태전체%방사면역측정%형광면역측정
Heart failure,congestive%Troponin Ⅰ%C-reactive protein%Plasma N-terminal pro-brain natriuretic peptide%Radioimmunoassary%Fluoroimmunoassay
目的 测定慢性心力衰竭(CHF)患者的血脂、血浆N氨基末端脑钠肽前体(NT-ProB-NP)、心肌肌钙蛋白Ⅰ(CTnⅠ)和高敏C反应蛋白(hs-CRP)水平并进行临床分析.方法 采用生化法、荧光免疫分析法和放射免疫分析法测定165例CHF患者和60名正常对照者的血脂和血浆NT-ProBNP、CTnⅠ和hs-CRP水平,并进行比较性分析.结果 165例CHF患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平较60名正常对照者明显降低(TC:tⅡ=2.214,P＜0.05; tⅢ=2.873,P＜0.01; tⅣ=3.146; P＜0.01; TG:tⅡ=2.167,P＜0.05; tⅢ=2.863,P＜0.01; tⅣ=3.063,P＜0.01; LDL-C:tⅡ=2.147,P＜0.05; tⅢ=2.056,P＜0.05; tⅣ=2.184,P＜0.05; HDL-C:tⅡ=2.137,P＜0.05; tⅢ=2.256,P＜0.05; tⅣ=3.148,P＜0.01).在生物标志物的测定中,165例CHF患者的血浆NT-ProBNP、CTnⅠ和hs-CRP水平与正常对照者之间的差异有统计学意义(NT-proBNP:tⅡ=2.096,P＞0.05; tⅢ=2.813,P＜0.01; tⅣ=4.135,P＜0.001;CTnⅠ:tⅡ=2.736,P＜0.01; tⅢ=2.962,P＜0.01; tⅣ=3.816,P＜0.001; hs-CRP:tⅡ=2.103,P＜0.05; tⅢ=2.956,P＜0.01;tⅣ=4.452,P＜0.001),而且随左心室射血功能(LVEF)的降低而逐步升高.结论 CHF患者血脂水平(TC、TG、LDL-C和HDL-C)随LVEF的降低而降低,具有血脂代谢紊乱的现象;血浆生物标志物水平(NT-ProBNP、CTnⅠ和hs-CRP)随LVEF的降低而升高.
目的 測定慢性心力衰竭(CHF)患者的血脂、血漿N氨基末耑腦鈉肽前體(NT-ProB-NP)、心肌肌鈣蛋白Ⅰ(CTnⅠ)和高敏C反應蛋白(hs-CRP)水平併進行臨床分析.方法 採用生化法、熒光免疫分析法和放射免疫分析法測定165例CHF患者和60名正常對照者的血脂和血漿NT-ProBNP、CTnⅠ和hs-CRP水平,併進行比較性分析.結果 165例CHF患者血清總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)和高密度脂蛋白膽固醇(HDL-C)水平較60名正常對照者明顯降低(TC:tⅡ=2.214,P＜0.05; tⅢ=2.873,P＜0.01; tⅣ=3.146; P＜0.01; TG:tⅡ=2.167,P＜0.05; tⅢ=2.863,P＜0.01; tⅣ=3.063,P＜0.01; LDL-C:tⅡ=2.147,P＜0.05; tⅢ=2.056,P＜0.05; tⅣ=2.184,P＜0.05; HDL-C:tⅡ=2.137,P＜0.05; tⅢ=2.256,P＜0.05; tⅣ=3.148,P＜0.01).在生物標誌物的測定中,165例CHF患者的血漿NT-ProBNP、CTnⅠ和hs-CRP水平與正常對照者之間的差異有統計學意義(NT-proBNP:tⅡ=2.096,P＞0.05; tⅢ=2.813,P＜0.01; tⅣ=4.135,P＜0.001;CTnⅠ:tⅡ=2.736,P＜0.01; tⅢ=2.962,P＜0.01; tⅣ=3.816,P＜0.001; hs-CRP:tⅡ=2.103,P＜0.05; tⅢ=2.956,P＜0.01;tⅣ=4.452,P＜0.001),而且隨左心室射血功能(LVEF)的降低而逐步升高.結論 CHF患者血脂水平(TC、TG、LDL-C和HDL-C)隨LVEF的降低而降低,具有血脂代謝紊亂的現象;血漿生物標誌物水平(NT-ProBNP、CTnⅠ和hs-CRP)隨LVEF的降低而升高.
목적 측정만성심력쇠갈(CHF)환자적혈지、혈장N안기말단뇌납태전체(NT-ProB-NP)、심기기개단백Ⅰ(CTnⅠ)화고민C반응단백(hs-CRP)수평병진행림상분석.방법 채용생화법、형광면역분석법화방사면역분석법측정165례CHF환자화60명정상대조자적혈지화혈장NT-ProBNP、CTnⅠ화hs-CRP수평,병진행비교성분석.결과 165례CHF환자혈청총담고순(TC)、감유삼지(TG)、저밀도지단백담고순(LDL-C)화고밀도지단백담고순(HDL-C)수평교60명정상대조자명현강저(TC:tⅡ=2.214,P＜0.05; tⅢ=2.873,P＜0.01; tⅣ=3.146; P＜0.01; TG:tⅡ=2.167,P＜0.05; tⅢ=2.863,P＜0.01; tⅣ=3.063,P＜0.01; LDL-C:tⅡ=2.147,P＜0.05; tⅢ=2.056,P＜0.05; tⅣ=2.184,P＜0.05; HDL-C:tⅡ=2.137,P＜0.05; tⅢ=2.256,P＜0.05; tⅣ=3.148,P＜0.01).재생물표지물적측정중,165례CHF환자적혈장NT-ProBNP、CTnⅠ화hs-CRP수평여정상대조자지간적차이유통계학의의(NT-proBNP:tⅡ=2.096,P＞0.05; tⅢ=2.813,P＜0.01; tⅣ=4.135,P＜0.001;CTnⅠ:tⅡ=2.736,P＜0.01; tⅢ=2.962,P＜0.01; tⅣ=3.816,P＜0.001; hs-CRP:tⅡ=2.103,P＜0.05; tⅢ=2.956,P＜0.01;tⅣ=4.452,P＜0.001),이차수좌심실사혈공능(LVEF)적강저이축보승고.결론 CHF환자혈지수평(TC、TG、LDL-C화HDL-C)수LVEF적강저이강저,구유혈지대사문란적현상;혈장생물표지물수평(NT-ProBNP、CTnⅠ화hs-CRP)수LVEF적강저이승고.
Objective To measure the levels of blood lipid and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP),cardiac troponin Ⅰ (CTnⅠ) and high sensitive C-reaction protein (hsCRP) in patients with chronic heart failure (CHF),and carry out clinical analysis.Methods The blood lipid and plasma NT-proBNP,CTnⅠ and hs-CRP levels in 165 patients with CHF and 60 controls were analyzed by chemistry,fluorescent immunoassay and radioimmunoassay,and then the results were analyzed and compared.Results The serum TC,TG,LDL-C and HDL-C levels in 165 patients with CHF were significantly lower than those of 60 controls (TC:t Ⅱ=2.214,P＜0.05; tⅢ=2.873,P＜0.01; tⅣ=3.146; P＜0.01;TG:t Ⅱ=2.167,P＜0.05; tⅢ=2.863,P＜0.01; tⅣ=3.063,P＜0.01; LDL-C:tⅡ=2.147,P＜0.05; tⅢ=2.056,P＜ 0.05; tⅣ=2.184,P＜0.05; HDL-C:tⅡ=2.137,P＜0.05; tⅢ=2.256,P＜0.05; tⅣ=3.148,P＜0.01).In biomarkers determining,the plasma NT-proBNP,CTnⅠ and hs-CRP levels in 165 patients with CHF were significantly higher than those of 60 controls (NT-proBNP:t Ⅱ=2.096,P＞0.05; tⅢ=2.813,P＜0.01; tⅣ=4.135,P＜0.001;CTnⅠ:tⅡ=2.736,P＜0.01; tⅢ=2.962,P＜0.01; tⅣ=3.816,P＜0.01 and hs-CRP:tⅡ=2.103,P＜0.05; tⅢ=2.956,P＜0.01; tⅣ=4.452,P＜0.001),and the plasma three biomarker levels were increased with decreasing left ventricular ejection function(LVEF).Conclusion The blood lipid (TC,TG,LDL-C and HDL-C) levels were decreased with decreasing LVEF and showing abnormal metabolism,but the plasma biomarkers levels were increased with decreasing LVEF.
