CAJ | 학술논문

乳腺癌是女性中最常见的恶性肿瘤之一,目前主要采取手术结合放化疗的综合治疗手段进行治疗,但是乳腺癌的异质性使得部分亚型尤其是三阴性乳腺癌的治疗疗效欠佳,预后也相对较差.目前研究表明Wnt/β-catenin信号通路异常表达在乳腺癌尤其是三阴性乳腺癌中广泛存在,其与乳腺癌的发生、发展、侵袭、转移和预后不良密切相关;抑制Wnt/β-catenin信号通路能有效抑制乳腺癌细胞的生长和对化疗药物的多药耐药,而且Wnt/β-catenin信号通路与辐射抗性密切相关.随着对Wnt/β-catenin信号通路的深入了解,它将有希望成为乳腺癌特别是三阴性乳腺癌靶向治疗和放射增敏治疗的新靶点.
유선암시녀성중최상견적악성종류지일,목전주요채취수술결합방화료적종합치료수단진행치료,단시유선암적이질성사득부분아형우기시삼음성유선암적치료료효흠가,예후야상대교차.목전연구표명Wnt/β-catenin신호통로이상표체재유선암우기시삼음성유선암중엄범존재,기여유선암적발생、발전、침습、전이화예후불량밀절상관;억제Wnt/β-catenin신호통로능유효억제유선암세포적생장화대화료약물적다약내약,이차Wnt/β-catenin신호통로여복사항성밀절상관.수착대Wnt/β-catenin신호통로적심입료해,타장유희망성위유선암특별시삼음성유선암파향치료화방사증민치료적신파점.
Breast cancer is one of the most common forms of cancer in women.The combination of surgery and radio-chemotherapy is the best treatment for breast cancer nowadays.However,due to heterogeneity of breast cancers,some subtypes of breast cancer,especially the triple negative breast cancer (TNBC),do not respond well to traditional therapy and has relatively poor prognosis.Recent studies indicate that the Wnt/β-catenin signaling pathway,which is particularly over-activated in breast cancer,especially in TNBC,is associated with the occurrence,development,invasion,metastasis and poor prognosis of breast cancer.Inhibition of Wnt/β-catenin signaling can effectively inhibits the growth of breast cancer cells and multidrug resistance in chemotherapy.Furthermore,Wnt/β-catenin signaling is also closely related to radiation resistance.Therefore,with a better understanding of Wnt/β-catenin signaling,it may be a new radio-chemotherapeutic target of breast cancer,especially for TNBC.