国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
20期
1525-1528
,共4页
王林林%时国朝%万欢英%汤葳%倪磊%朱海星%侯小霞%潘丽娜%石宝玉%陶连琴
王林林%時國朝%萬歡英%湯葳%倪磊%硃海星%侯小霞%潘麗娜%石寶玉%陶連琴
왕림림%시국조%만환영%탕위%예뢰%주해성%후소하%반려나%석보옥%도련금
过敏性哮喘%调节性T细胞%表达IL-4受体的调节性T细胞%第一秒用力呼气容积占预计值百分比%哮喘控制问卷
過敏性哮喘%調節性T細胞%錶達IL-4受體的調節性T細胞%第一秒用力呼氣容積佔預計值百分比%哮喘控製問捲
과민성효천%조절성T세포%표체IL-4수체적조절성T세포%제일초용력호기용적점예계치백분비%효천공제문권
Allergic asthma%Treg%IL-4R+Treg%FEV1％ pred%Asthma control questionnaire
目的 初步探讨表达IL-4受体的调节性T细胞(IL-4R+ Treg)在过敏性哮喘中的临床意义.方法 本研究纳入对屋尘螨过敏的20例哮喘患者作为研究对象,行肺功能检查和哮喘控制问卷(asthma control questionnaire,ACQ)调查,20名健康志愿者作为对照组.采用流式细胞术检测外周血IL-4R+ Treg/Treg百分比.结果 间歇轻度组(n=12)、中重度组(n=8)和正常对照组(n=20)IL-4R+ Treg/Treg％分别为(4.24±2.14)％、(14.56±4.19)％和(1.04±0.54)％,各组之间差异有统计学意义(P＜0.001).哮喘组IL-4R+ Treg/Treg％与FEV1％预计值呈显著负相关性(r=-0.512,P＜0.05),与ACQ得分呈显著正相关性(r=0.592,P＜0.01).结论 Treg表达的IL-4R在过敏性哮喘的免疫反应中可能发挥重要作用,IL-4R+ Treg细胞数量的增多可导致哮喘患者体内免疫失衡而促进哮喘的发生发展.
目的 初步探討錶達IL-4受體的調節性T細胞(IL-4R+ Treg)在過敏性哮喘中的臨床意義.方法 本研究納入對屋塵螨過敏的20例哮喘患者作為研究對象,行肺功能檢查和哮喘控製問捲(asthma control questionnaire,ACQ)調查,20名健康誌願者作為對照組.採用流式細胞術檢測外週血IL-4R+ Treg/Treg百分比.結果 間歇輕度組(n=12)、中重度組(n=8)和正常對照組(n=20)IL-4R+ Treg/Treg％分彆為(4.24±2.14)％、(14.56±4.19)％和(1.04±0.54)％,各組之間差異有統計學意義(P＜0.001).哮喘組IL-4R+ Treg/Treg％與FEV1％預計值呈顯著負相關性(r=-0.512,P＜0.05),與ACQ得分呈顯著正相關性(r=0.592,P＜0.01).結論 Treg錶達的IL-4R在過敏性哮喘的免疫反應中可能髮揮重要作用,IL-4R+ Treg細胞數量的增多可導緻哮喘患者體內免疫失衡而促進哮喘的髮生髮展.
목적 초보탐토표체IL-4수체적조절성T세포(IL-4R+ Treg)재과민성효천중적림상의의.방법 본연구납입대옥진만과민적20례효천환자작위연구대상,행폐공능검사화효천공제문권(asthma control questionnaire,ACQ)조사,20명건강지원자작위대조조.채용류식세포술검측외주혈IL-4R+ Treg/Treg백분비.결과 간헐경도조(n=12)、중중도조(n=8)화정상대조조(n=20)IL-4R+ Treg/Treg％분별위(4.24±2.14)％、(14.56±4.19)％화(1.04±0.54)％,각조지간차이유통계학의의(P＜0.001).효천조IL-4R+ Treg/Treg％여FEV1％예계치정현저부상관성(r=-0.512,P＜0.05),여ACQ득분정현저정상관성(r=0.592,P＜0.01).결론 Treg표체적IL-4R재과민성효천적면역반응중가능발휘중요작용,IL-4R+ Treg세포수량적증다가도치효천환자체내면역실형이촉진효천적발생발전.
Objective To investigate the clinical significance of regulatory T cells with IL-4R expression (IL-4R+ Treg) in allergic asthma.Methods 20 patients with chronic persistent asthma were enrolled,lung function was tested and asthma control questionnaire (ACQ) was recorded.20 healthy donors were enrolled as control.The proportions of IL-4R+ Treg in peripheral blood were determined by flow cytometry.Results The percentages of IL-4R+ Treg/Treg in peripheral blood with intermittent-mild and moderate-severe asthma were higher than that in healthy controls [(4.24 ± 2.14)％ vs (1.04±0.54) ％,P ＜0.001];[(14.56±4.19) ％ vs (1.04±0.54) ％,P ＜0.001],and intermittent-mild asthma was significantly lower than moderate-severe asthma [(4.24 ± 2.14)％ vs (14.56 ±4.19)％,P ＜0.001].The percentage of IL-4R+ Treg/Treg in peripheral blood with asthma was negatively associated with FEV1％pred (r =-0.512,P ＜0.05),and positively associated with the score of ACQ(r =0.592,P ＜0.01).Conclusions We speculated IL-4R expressed by Treg play an important role in patients with asthma on the immune response,the increased number of IL-4R+ Treg resulted in immune response imbalances and promote the occurrence and progress of asthma.
