国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
20期
1570-1574
,共5页
支气管哮喘%肺水通道蛋白
支氣管哮喘%肺水通道蛋白
지기관효천%폐수통도단백
Bronchial asthma%Lung Aquaporins
通过对肺水通道蛋白(aquaporins,AQPs)的结构、分布及功能的研究,发现AQPs与支气管哮喘(简称哮喘)之间存在密切关系,其中,AQP1参与了肺部水的转运、哮喘急性炎症期的发病机制,AQP3可能在保持气道表面的液体平衡及防止细菌入侵、气道重塑等方面起着重要的作用,AQP4可能参与了哮喘条件下黏液分泌的调控,AQP5则与气道高反应性、气流受限、调节气道水稳态有关,这些为哮喘的诊断及治疗开辟了新的思路.
通過對肺水通道蛋白(aquaporins,AQPs)的結構、分佈及功能的研究,髮現AQPs與支氣管哮喘(簡稱哮喘)之間存在密切關繫,其中,AQP1參與瞭肺部水的轉運、哮喘急性炎癥期的髮病機製,AQP3可能在保持氣道錶麵的液體平衡及防止細菌入侵、氣道重塑等方麵起著重要的作用,AQP4可能參與瞭哮喘條件下黏液分泌的調控,AQP5則與氣道高反應性、氣流受限、調節氣道水穩態有關,這些為哮喘的診斷及治療開闢瞭新的思路.
통과대폐수통도단백(aquaporins,AQPs)적결구、분포급공능적연구,발현AQPs여지기관효천(간칭효천)지간존재밀절관계,기중,AQP1삼여료폐부수적전운、효천급성염증기적발병궤제,AQP3가능재보지기도표면적액체평형급방지세균입침、기도중소등방면기착중요적작용,AQP4가능삼여료효천조건하점액분비적조공,AQP5칙여기도고반응성、기류수한、조절기도수은태유관,저사위효천적진단급치료개벽료신적사로.
By the researches of Lung Aquaporins' structure,distribution and function,it is discovered that Lung Aquaporins are closely associated with bronchial asthma,among of them,AQP1 participates in the transportation of the lung water and the pathogenesis of asthma' acute inflammatory period; AQP3 may play an important part in keeping the water balance of the air passage’ surface,and preventing the invading of bacteria,remodeling of air passage; AQP4 may participates in the regulation of mucus secreting under asthma; AQP5 is connected with airway hyperreactivity,airflow limitation,and airway water balance regulation,all of these open up new ideas of asthma' diagnosis and treatment.