国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
21期
1633-1636
,共4页
沈凌%王利民%祁明浩%任振义
瀋凌%王利民%祁明浩%任振義
침릉%왕이민%기명호%임진의
骨桥蛋白%胸腔积液%肿瘤标志物%肺癌
骨橋蛋白%胸腔積液%腫瘤標誌物%肺癌
골교단백%흉강적액%종류표지물%폐암
Osteopontin%Pleural effusion%Tumor markers%Lung cancer
目的 通过检测胸腔积液中骨桥蛋白(OPN)和癌胚抗原(CEA)、CA199的水平,探讨联合检测三项指标对于胸腔积液鉴别诊断的临床应用价值.方法 收集2009年10月至2011年1月在杭州市第一人民医院呼吸科住院的胸腔积液患者85例,其中恶性胸腔积液39例,良性胸腔积液46例(其中结核性胸腔积液,肺炎旁胸腔积液30例).取第一次胸腔穿刺术所得的胸腔积液标本,应用酶联免疫吸附试验法测定胸腔积液中OPN浓度.结果 恶性胸腔积液中OPN浓度显著高于良性胸腔积液,与良性胸腔积液中各亚组比较差异均有统计学意义(P＜0.01).根据ROC曲线,取OPN浓度2 000 ng/L为临界值,诊断恶性胸腔积液的敏感性为71.8％,特异性为95.7％,准确性为84.8％.联合检测OPN和CEA诊断恶性胸腔积液的敏感性为97.43％,特异性为95.65％,准确性为96.47％.结论 测定胸腔积液中OPN浓度对鉴别良性、恶性胸腔积液有一定价值,与CEA联合诊断恶性胸腔积液时敏感性和特异性进一步提高,值得在临床推广.
目的 通過檢測胸腔積液中骨橋蛋白(OPN)和癌胚抗原(CEA)、CA199的水平,探討聯閤檢測三項指標對于胸腔積液鑒彆診斷的臨床應用價值.方法 收集2009年10月至2011年1月在杭州市第一人民醫院呼吸科住院的胸腔積液患者85例,其中噁性胸腔積液39例,良性胸腔積液46例(其中結覈性胸腔積液,肺炎徬胸腔積液30例).取第一次胸腔穿刺術所得的胸腔積液標本,應用酶聯免疫吸附試驗法測定胸腔積液中OPN濃度.結果 噁性胸腔積液中OPN濃度顯著高于良性胸腔積液,與良性胸腔積液中各亞組比較差異均有統計學意義(P＜0.01).根據ROC麯線,取OPN濃度2 000 ng/L為臨界值,診斷噁性胸腔積液的敏感性為71.8％,特異性為95.7％,準確性為84.8％.聯閤檢測OPN和CEA診斷噁性胸腔積液的敏感性為97.43％,特異性為95.65％,準確性為96.47％.結論 測定胸腔積液中OPN濃度對鑒彆良性、噁性胸腔積液有一定價值,與CEA聯閤診斷噁性胸腔積液時敏感性和特異性進一步提高,值得在臨床推廣.
목적 통과검측흉강적액중골교단백(OPN)화암배항원(CEA)、CA199적수평,탐토연합검측삼항지표대우흉강적액감별진단적림상응용개치.방법 수집2009년10월지2011년1월재항주시제일인민의원호흡과주원적흉강적액환자85례,기중악성흉강적액39례,량성흉강적액46례(기중결핵성흉강적액,폐염방흉강적액30례).취제일차흉강천자술소득적흉강적액표본,응용매련면역흡부시험법측정흉강적액중OPN농도.결과 악성흉강적액중OPN농도현저고우량성흉강적액,여량성흉강적액중각아조비교차이균유통계학의의(P＜0.01).근거ROC곡선,취OPN농도2 000 ng/L위림계치,진단악성흉강적액적민감성위71.8％,특이성위95.7％,준학성위84.8％.연합검측OPN화CEA진단악성흉강적액적민감성위97.43％,특이성위95.65％,준학성위96.47％.결론 측정흉강적액중OPN농도대감별량성、악성흉강적액유일정개치,여CEA연합진단악성흉강적액시민감성화특이성진일보제고,치득재림상추엄.
Objective To investigate the value of osteopontin(OPN) in the differential diagnosis of pleural effusion.Methods A total of 85 patients with pleural effusion during October 2009 to January 2011 were recruited at the department of respiratory medicine of Hangzhou First Hospital.Pleural effusion was malignant in 39 cases and benign in 46 cases.The patients were divided into a malignant pleural effusion group,an infective pleural effusion group,and a transudation group.Then the infective was further divided into subgroup of tuberculosis pleural effusion group and parapneumonic effusion group.Results The concentration of OPN was significantly higher in the malignant pleural effusion group compared with the benign pleural effusion groups (P ＜70.01).When the cutoff value of OPN was set at 2 000 ng/L,the sensitivity specificity and accuracy for the diagnosis of malignant pleural effusion was 71.8％,95.7％ and 84.8％,respectively.Furthermore,the detection of OPN in combination with CEA showed better diagnostic sensitivity (97.43％),specificity (95.65％),and accuracy (96.47％).Conclusions The detection of OPN in pleural effusion is of some clinical significance in the differential diagnosis of malignant and benign pleural effusion.
