CAJ | 학술논문

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)可引起患者认知障碍,其发生机制主要与睡眠结构紊乱以及慢性间断性低氧血症有关,而缺氧敏感区脑组织的病理改变则可能是认知障碍产生的病理基础.初步研究表明OSAHS认知障碍表现为全面认知功能缺损,且可能与阿尔茨海默病有一定的相关性.儿童OSAHS的发病并不少见且可能影响到儿童的认知行为发育,需引起足够的重视.近年来,神经影像技术的应用拓展了认知功能的评估手段,但仍有待建立一套特异性高、操作性强的临床评价体系.早期积极治疗OSAHS可减缓认知障碍的发生,而莫达非尼等药物对改善OSAHS患者的认知障碍带来新的希望.
조새성수면호흡잠정저통기종합정(OSAHS)가인기환자인지장애,기발생궤제주요여수면결구문란이급만성간단성저양혈증유관,이결양민감구뇌조직적병리개변칙가능시인지장애산생적병리기출.초보연구표명OSAHS인지장애표현위전면인지공능결손,차가능여아이자해묵병유일정적상관성.인동OSAHS적발병병불소견차가능영향도인동적인지행위발육,수인기족구적중시.근년래,신경영상기술적응용탁전료인지공능적평고수단,단잉유대건립일투특이성고、조작성강적림상평개체계.조기적겁치료OSAHS가감완인지장애적발생,이막체비니등약물대개선OSAHS환자적인지장애대래신적희망.
Patients possibly incur cognitive disorders when they suffer from obstructive sleep apnea-hypopnea syndrome(OSAHS).The pathogenesis of OSAHS is mainly associated with turbulence of sleep structure and intermittent hypoxia during sleep,and the pathological changes in cerebral areas hypersensitive to hypopnea may be responsible for cognitive dysfunction.It has been preliminarily showed that cognitive disorder in OSAHS is a generalized cognitive impairment and is possibly associated with Alzheimer's disease.Recently,measures for cognitive evaluation have been improved by the application of the neuroimage,however,to build a highly specific,maneuverable evaluation system still demands more exertion.Despite the fact that early remedies for OSAHS may slow down the cognitive dysfunction,there still lacks specialized treatment for cognitive disorders.OSAHS is not rare in children and it can affect their cognitive function,which demands more attention.