CAJ | 학술논문

肺泡巨噬细胞作为常驻肺部的主要固有免疫细胞,在急性肺损伤(ALI)的发生、发展以及转归过程中发挥了十分重要的作用.在ALI早期,肺部固有巨噬细胞通过释放趋化因子募集更多的外周巨噬细胞及中性粒细胞至炎症部位,启动肺部炎症反应.随着炎症的进一步发展,肺泡巨噬细胞功能的适度发挥调节中性粒细胞的过度激活从而控制炎症的失控性进展.在ALI晚期,肺泡巨噬细胞再次通过清除凋亡的炎症细胞加速炎症的消退,从而影响ALI的转归及预后.
폐포거서세포작위상주폐부적주요고유면역세포,재급성폐손상(ALI)적발생、발전이급전귀과정중발휘료십분중요적작용.재ALI조기,폐부고유거서세포통과석방추화인자모집경다적외주거서세포급중성립세포지염증부위,계동폐부염증반응.수착염증적진일보발전,폐포거서세포공능적괄도발휘조절중성립세포적과도격활종이공제염증적실공성진전.재ALI만기,폐포거서세포재차통과청제조망적염증세포가속염증적소퇴,종이영향ALI적전귀급예후.
The alveolar macrophage is the main resident natural immune cells in the lung,which plays an important role in the occurrence,development and complete resolution of acute lung injury.In the early stage,the resident alveolar macrophages recruit exudated macrophages and neutrophils by releasing chemokines and start inflammation progress.With the further development of inflammation,the regulation of alveolar macrophage inhibit the excessive activation of neutrophils and control inflammation progress.In the late stage,the alveolar macrophages undergo apoptosis during resolving inflammation,which affect the resolution and prognosis of acute lung injury.