CAJ | 학술논문

热休克蛋白47(HSP47)是胶原结合分子伴侣,参与前胶原的加工、折叠、合成及分泌,起着质量控制作用.肺纤维化存在胶原异常聚集及HSP47表达增多.在各种不同类型肺纤维化中,HSP47表达上调,与胶原表达正相关,但不同类型肺纤维化HSP47表达水平各异.现就HSP47在肺纤维化胶原表达加工的作用综述如下.
열휴극단백47(HSP47)시효원결합분자반려,삼여전효원적가공、절첩、합성급분비,기착질량공제작용.폐섬유화존재효원이상취집급HSP47표체증다.재각충불동류형폐섬유화중,HSP47표체상조,여효원표체정상관,단불동류형폐섬유화HSP47표체수평각이.현취HSP47재폐섬유화효원표체가공적작용종술여하.
Heat shock protein 47(HSP47) was a collagen-specific molecular chaperon.It was found to participate in pro-collagen processing,folding,synthesis and secretion,functioned as "quality control".HSP47 was upregulated and had positive relation with collagen expression which was abnormally aggregated in pulmonary fibrosis.Increased expression of HSP47 was found in various pulmonary fibrotic diseases with different level.Here we reviewed the articles about the function of HSP47 in collagen processing of pulmonary fibrosis.