CAJ | 학술논문

目的观察甘露聚糖肽对结核性胸膜炎患者的临床疗效.方法 68例入选患者随机分为观察组和对照组,采用单盲法对比研究.观察组采用甘露聚糖肽2 ml(5 mg)每日注射+常规治疗方法,对照组采用生理盐水2 ml每日注射+常规治疗方法,对比不同治疗阶段患者胸穿后取胸水使用ELISA法检测γ干扰素(INF-γ)、白介素4(IL-4)表达情况.结果观察组治疗5d、10 d后胸水INF-γ表达高于对照组(P＜0.05),而IL-4表达低于对照组(P＜0.05).结论甘露聚糖肽对结核性胸膜炎患者胸水中的免疫细胞有明显的免疫调节作用,能有较好的辅助治疗效果.
목적 관찰감로취당태대결핵성흉막염환자적림상료효.방법 68례입선환자수궤분위관찰조화대조조,채용단맹법대비연구.관찰조채용감로취당태2 ml(5 mg)매일주사+상규치료방법,대조조채용생리염수2 ml매일주사+상규치료방법,대비불동치료계단환자흉천후취흉수사용ELISA법검측γ간우소(INF-γ)、백개소4(IL-4)표체정황.결과 관찰조치료5d、10 d후흉수INF-γ표체고우대조조(P＜0.05),이IL-4표체저우대조조(P＜0.05).결론 감로취당태대결핵성흉막염환자흉수중적면역세포유명현적면역조절작용,능유교호적보조치료효과.
Objective To investigate the clinical effect of Mannatide injection in Tuberculous pleuritis patients.Methods 68 patients were randomly divided into treatment group and control group.To study with single-blinded study of the control method.Inject 2 ml(5 mg) of Mannatide injection to treatment groups one time each day,and at the same time give them the conventional treatment,inject 2 ml of normal saline to control groups with taking conventional treatment,observe the expression of INF-γ,IL-4 by ELISA dyeing method in hydrothorax of different patients in different therapy phase.Results 5 days and 10 days after treatment,the expression of INF-γ in hydrothorax of treatment groups is higher than the control groups (P ＜0.05),meanwhile,the expression of IL-4 in hydrothorax of the reatment groups is less than the control groups.Conclusions Mannatide injection have the immune adjustment function to immune cell in hydrothorax of Tuberculous pleuritis patients,and have the better Medicinal cure effect.