CAJ | 학술논문

目的探讨结核分枝杆菌临床分离株对异烟肼(isonicotinyl hydrazide,H)、利福平(rifampicin,R)、链霉素(streptomycin,S)的依赖情况.方法采集128份自2008年1月至2009年6月在北京胸科医院住院治疗的肺结核患者的痰液标本,采用改良罗氏培养基分离菌株,并进行菌株耐药性及药物依赖性测定.结果 65株菌株对H和(或)R和(或)S耐药,占50.8％ (65/128),12株对药物产生了依赖性,占9.4％(12/128),其中依赖H、R、S分别占0.8％(1/128)、7.0％(9/128)、3.9％(5/128),同时依赖RS占2.3％(3/128).结论结核分枝杆菌临床分离株中存在H、R、S依赖菌株,临床实践中,需及时调整治疗方案,提高结核病治愈率.
목적 탐토결핵분지간균림상분리주대이연정(isonicotinyl hydrazide,H)、리복평(rifampicin,R)、련매소(streptomycin,S)적의뢰정황.방법 채집128빈자2008년1월지2009년6월재북경흉과의원주원치료적폐결핵환자적담액표본,채용개량라씨배양기분리균주,병진행균주내약성급약물의뢰성측정.결과 65주균주대H화(혹)R화(혹)S내약,점50.8％ (65/128),12주대약물산생료의뢰성,점9.4％(12/128),기중의뢰H、R、S분별점0.8％(1/128)、7.0％(9/128)、3.9％(5/128),동시의뢰RS점2.3％(3/128).결론 결핵분지간균림상분리주중존재H、R、S의뢰균주,림상실천중,수급시조정치료방안,제고결핵병치유솔.
Objective To investigate the drug dependency on H,R and S of clinical isolated strains of M.tuberculosis(MTB).Methods During a period from the January,2008 to the June,2009,128 cases chemotherapy for pulmonary tuberculosis were received in Beijing Chest Hospital.In accordance with tuberculosis diagnostic laboratory tests procedures,128 sputum samples were inoculated to LowensteinJensen medium.Susceptibility testing and drug dependency testing were performed for the culturepositive strains.Results 65 clinical isolated strains were resistant to H and (or) R and (or) S,and the resistant rate was 50.8％ (65/128).12 strains were dependent on the anti-TB drugs,the drug-dependent rate of H,R,S and RS was 0.8％ (1/128),7.0％ (9/128),3.9％ (5/128),and 2.3％(3/128),respectively,and the totally drug-dependent rate was 9.4％ (12/128).Conclusions The drug-dependent strains on H,R and S did exist in the clinical isolated strains of MTB.In clinical practice,we should adjust the treatment regimen in time,to improve the cure rate.