国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
23期
1788-1790
,共3页
帅智闯%卢丽%董会升%丁东
帥智闖%盧麗%董會升%丁東
수지틈%로려%동회승%정동
阻塞性睡眠呼吸暂停低通气综合征%甲状腺素%持续气道正压通气
阻塞性睡眠呼吸暫停低通氣綜閤徵%甲狀腺素%持續氣道正壓通氣
조새성수면호흡잠정저통기종합정%갑상선소%지속기도정압통기
Obstructive sleep apnea hypopnea syndrome%Thyroxine%Continuing positive airway pressure
目的 探讨甲状腺素联合持续气道正压通气(CPAP)在治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)中的疗效,提高临床诊治水平.方法 对81例患有OSAHS患者随即分成两组(治疗组43例,对照组38例),两组应用不同诊治方式,对治疗后多导睡眠图监测数据进行回顾性分析.结果 两组患者在各研究时间段(治疗前,治疗3个月后,治疗6个月后,治疗12个月后)一般精神状态、AHI、治疗组的SaO2在同组内比较均较前阶段有明显改善,AHI和治疗组的SaO2在各研究时间段比较差异有统计学意义(P ＜0.05).两组患者在研究的相同时间段内比较,AHI在各研究时间段两组比较差异均有统计学意义；两组患者的SO2在治疗6个月后和治疗12个月后比较差异有统计学意义(P＜0.05).治疗组BMI在各研究时间段内组间比较差异均有统计学意义(P＜0.05),而对照组在前半年组间比较差异有统计学意义(P ＜0.05),半年后组间比较则差异无统计学意义.结论 OSAHS患者在CPAP治疗基础上口服小剂量甲状腺素治疗效果更好.
目的 探討甲狀腺素聯閤持續氣道正壓通氣(CPAP)在治療阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)中的療效,提高臨床診治水平.方法 對81例患有OSAHS患者隨即分成兩組(治療組43例,對照組38例),兩組應用不同診治方式,對治療後多導睡眠圖鑑測數據進行迴顧性分析.結果 兩組患者在各研究時間段(治療前,治療3箇月後,治療6箇月後,治療12箇月後)一般精神狀態、AHI、治療組的SaO2在同組內比較均較前階段有明顯改善,AHI和治療組的SaO2在各研究時間段比較差異有統計學意義(P ＜0.05).兩組患者在研究的相同時間段內比較,AHI在各研究時間段兩組比較差異均有統計學意義；兩組患者的SO2在治療6箇月後和治療12箇月後比較差異有統計學意義(P＜0.05).治療組BMI在各研究時間段內組間比較差異均有統計學意義(P＜0.05),而對照組在前半年組間比較差異有統計學意義(P ＜0.05),半年後組間比較則差異無統計學意義.結論 OSAHS患者在CPAP治療基礎上口服小劑量甲狀腺素治療效果更好.
목적 탐토갑상선소연합지속기도정압통기(CPAP)재치료조새성수면호흡잠정저통기종합정(OSAHS)중적료효,제고림상진치수평.방법 대81례환유OSAHS환자수즉분성량조(치료조43례,대조조38례),량조응용불동진치방식,대치료후다도수면도감측수거진행회고성분석.결과 량조환자재각연구시간단(치료전,치료3개월후,치료6개월후,치료12개월후)일반정신상태、AHI、치료조적SaO2재동조내비교균교전계단유명현개선,AHI화치료조적SaO2재각연구시간단비교차이유통계학의의(P ＜0.05).량조환자재연구적상동시간단내비교,AHI재각연구시간단량조비교차이균유통계학의의；량조환자적SO2재치료6개월후화치료12개월후비교차이유통계학의의(P＜0.05).치료조BMI재각연구시간단내조간비교차이균유통계학의의(P＜0.05),이대조조재전반년조간비교차이유통계학의의(P ＜0.05),반년후조간비교칙차이무통계학의의.결론 OSAHS환자재CPAP치료기출상구복소제량갑상선소치료효과경호.
Objective To explore the effect of thyroxine joint continuing positive airway pressure (CPAP) in the treatment of obstructive sleep apnea hypopnea syndrome (OSAHS),and improve the level of clinic diagnosis and treatment.Methods 81 cases of patients suffering from OSAHS were randomly divided into two groups (43 in the treatment group,and 38 in the control group),to which two different diagnosis and treatment modalities were applied respectively.Then retrospectively analyzed the monitoring data of polysomnography (PSG) after the treatment.Results In the study period (before treatment,3 months,6 months and 12 months after treatment),the general state of mind,AHI of both groups and the SaO2 of the treatment group (compared in the same group) were all better than the previous stages,and there were significant differences between AHI and SaO2 of the treatment group (P ＜0.05).In the same study period,there were significance to AHI between two groups.There were significance to SO2 of both groups 6 months later and 12 months later after the treatment (P ＜0.05).There were significant differences in BMI of the treatment group between two groups in all study period (P ＜0.05),while there were significant differences of the other group during the first six months (P ＜0.05),and no significant differences six months later.Conclusions On the basis of CPAP treatment,Oral administration of small doses of thyroxine is better for patients of OSAHS.
