CAJ | 학술논문

目的评价降钙素原(PCT)在下呼吸道感染性疾病的早期诊断及鉴别诊断中的价值.方法依据胸片、症状、体征及病原学检查,将我院收治的32例非典型下呼吸道感染患者作为对照组(细菌性感染19例,非细菌性感染13例),30例典型下呼吸道感染患者作为实验组(细菌性感染16例,非细菌性感染14例).应用半定量固相免疫法测定血清PCT,应用免疫透射比浊法测定血清C反应蛋白(CRP),对两组患者PCT、CRP值,以及细菌性感染和非细菌性感染患者血清PCT、CRP值进行统计学分析.结果两组细菌性感染患者PCT及CRP的差异均具有统计学意义；非细菌性感染患者PCT及CRP的组间差异均无统计学意义.实验组与对照组比较,PCT差异具有统计学意义,但CRP差异无统计学意义.结论与CRP相比,PCT敏感性更高,特异性更强.血清PCT在下呼吸道感染性疾病早期诊断和细菌性感染鉴别诊断中有重要价值,且对于下呼吸道感染性疾病的早期诊断价值要优于CRP.
목적 평개강개소원(PCT)재하호흡도감염성질병적조기진단급감별진단중적개치.방법 의거흉편、증상、체정급병원학검사,장아원수치적32례비전형하호흡도감염환자작위대조조(세균성감염19례,비세균성감염13례),30례전형하호흡도감염환자작위실험조(세균성감염16례,비세균성감염14례).응용반정량고상면역법측정혈청PCT,응용면역투사비탁법측정혈청C반응단백(CRP),대량조환자PCT、CRP치,이급세균성감염화비세균성감염환자혈청PCT、CRP치진행통계학분석.결과 량조세균성감염환자PCT급CRP적차이균구유통계학의의；비세균성감염환자PCT급CRP적조간차이균무통계학의의.실험조여대조조비교,PCT차이구유통계학의의,단CRP차이무통계학의의.결론 여CRP상비,PCT민감성경고,특이성경강.혈청PCT재하호흡도감염성질병조기진단화세균성감염감별진단중유중요개치,차대우하호흡도감염성질병적조기진단개치요우우CRP.
Objective To evaluate the value of procalciton in early diagnosis and differential diagnosis of lower respiratory tract infectious diseases.Methods Based on X-ray chest film,signs,symptoms,and etiological examine,32 patients suffered from atypical lower respiratory tract infection were set as control group,including 19 patients with bacterial infection and 13 patients with non-bacterial infection,moreover,30 patients suffered from typical lower respiratory tract infection were set as experimental group,including 16 patients with bacterial infection and 14 patients with non-bacterial infection.Serum procalciton was tested by semiquantitative solid phase immune method,and serum C-reaction protein was tested by immune transmission turbidimetry method.The procalciton and C-reaction protein were compared between two groups,and between the patients with bacterial infection and with non-bacterial infection,and then the statistic analysis was performed.Results The procalciton and C-reaction protein of the patients with bacterial infection showed statistic differences between two groups,moreover,procalciton and C-reaction protein of the patients with non-bacterial infection showed no statistic difference.Compared to control group,the procalciton in experiment group showed statistic difference,but the C-reaction protein showed no statistic difference.Conclusions Compared to C-reaction protein,procalciton shows higher sensitivity and better specificity.Serum procalciton shows significant value in early diagnosis in lower respiratory tract infection and differential diagnosis in bacterial infection,moreover,it is better than C-reaction protein to perform early diagnosis in lower respiratory tract infection diseases.