CAJ | 학술논문

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种具有气流受限为特征的肺部疾病,骨骼肌功能障碍(skeletal muscle dysfunction,SMD)是常见的并发症.目前研究多认为其主要发病机制为营养不良、慢性缺氧、炎症反应、氧化应激以及蛋白合成与分解失衡等.本文对近年来COPD合并SMD的相关机制研究进行综述,为进一步开展相关研究提供依据.
만성조새성폐질병(chronic obstructive pulmonary disease,COPD)시일충구유기류수한위특정적폐부질병,골격기공능장애(skeletal muscle dysfunction,SMD)시상견적병발증.목전연구다인위기주요발병궤제위영양불량、만성결양、염증반응、양화응격이급단백합성여분해실형등.본문대근년래COPD합병SMD적상관궤제연구진행종술,위진일보개전상관연구제공의거.
Chronic obstructive pulmonary disease (COPD) is a disease characterized by airflow limitation,and skeletal muscle dysfunction (SMD) as a common complications.Most researches considered that its main pathogenesis were malnutrition,chronic hypoxia,inflammation,oxidative stress and imbalance of protein synthesis and degradation.This review focuses on recent mechanism studies of COPD complicated with SMD,and provides basis for further research.