CAJ | 학술논문

慢性阻塞性肺疾病(COPD)的心血管疾病患病率及病死率均增加,可能与COPD患者血管内皮功能障碍有关,其中内皮祖细胞数量与功能下降起着重要作用.此外,系统性炎症反应、氧化/抗氧化失衡、蛋白酶/抗蛋白酶失衡等机制亦导致COPD患者心血管事件风险增加.在COPD患者中早期监测循环血中心血管事件的分子标志物如BNP、hsCRP、SAA、MMPs等有助于早期诊断和指导治疗共患的心血管疾病.
만성조새성폐질병(COPD)적심혈관질병환병솔급병사솔균증가,가능여COPD환자혈관내피공능장애유관,기중내피조세포수량여공능하강기착중요작용.차외,계통성염증반응、양화/항양화실형、단백매/항단백매실형등궤제역도치COPD환자심혈관사건풍험증가.재COPD환자중조기감측순배혈중심혈관사건적분자표지물여BNP、hsCRP、SAA、MMPs등유조우조기진단화지도치료공환적심혈관질병.
Cardiovascular morbidity and mortality in chronic obstructive pulmonary disease (COPD) are increased.The underlying mechanism might be linked to endothelial dysfunction of COPD,where the lower number and dysfunction of endothelial progenitor cells play an important role.Moreover,systemic inflammation,oxidative stress,imbalance of protease and antiprotease all increase the cardiovascular risk in COPD.Early detect of biological markers of cardiovascular diseases including BNP,hsCRP,SAA,MMPs might help to more accurately predict the onset of COPD-related cardiovascular events and guide appropriate therapy.