CAJ | 학술논문

目的研究紫杉醇+顺铂二线治疗复治小细胞肺癌患者的疗效和毒副反应.方法纳入一线含铂方案(依托泊苷+卡铂)化疗失败患者38例,采用紫杉醇135 mg/m2,第1天；顺铂70 mg/m2,第1～3天,每3～4周为1个周期,连用2～4个周期.结果部分缓解12例,稳定14例,进展12例,总有效率31.6％(12/38),疾病控制率68.4％(26/38),总生存期10.5个月,中位生存期6.8个月.化疗敏感者有效率39.3％(11/28);化疗耐药者有效率10.0％(1/10).本组38例均可评价毒副反应,Ⅲ度以上白细胞及中性粒细胞减少分别为47.4％(18/38)、57.9％(22/38).Ⅳ度中性粒细胞减少15.8％(6/38).中性粒细胞减少性发热10.5％(4/38).主要非血液学毒副反应是乏力、恶心呕吐、周围神经毒性,Ⅲ度以上毒性反应是乏力55.3％(21/38)、恶心呕吐31.6％(12/38).结论紫杉醇+顺铂治疗复治小细胞肺癌有效且毒副反应可耐受.
목적 연구자삼순+순박이선치료복치소세포폐암환자적료효화독부반응.방법 납입일선함박방안(의탁박감+잡박)화료실패환자38례,채용자삼순135 mg/m2,제1천；순박70 mg/m2,제1～3천,매3～4주위1개주기,련용2～4개주기.결과 부분완해12례,은정14례,진전12례,총유효솔31.6％(12/38),질병공제솔68.4％(26/38),총생존기10.5개월,중위생존기6.8개월.화료민감자유효솔39.3％(11/28);화료내약자유효솔10.0％(1/10).본조38례균가평개독부반응,Ⅲ도이상백세포급중성립세포감소분별위47.4％(18/38)、57.9％(22/38).Ⅳ도중성립세포감소15.8％(6/38).중성립세포감소성발열10.5％(4/38).주요비혈액학독부반응시핍력、악심구토、주위신경독성,Ⅲ도이상독성반응시핍력55.3％(21/38)、악심구토31.6％(12/38).결론 자삼순+순박치료복치소세포폐암유효차독부반응가내수.
Objective To investigate the activity and toxicity of paclitaxol plus cisplatin in secondline treatment of small cell lung cancer.Methods Thirty-eight patients were enrolled and received paclitaxol 135 mg/m2 d1,cisplatin 70 mg/m2 d1-3.All treatment was delivered every three or four weeks.Results One patient was failing to complete the treatment by the side effects.Thirty-seven patients were valuable for response.Twelve partial responses were observed,overall response rate was 31.6 ％,control rate of disease was 68.4％,and the median duration was 6.8 months.Thirty-eight patients were evaluating for toxicity.WHO grade Ⅲ leucopoenia,neutrogena occurred in 47.4％,57.9％,grade Ⅳ neutropenia in 15.8％ cases.WHO grade Ⅲ fatigue and vomit occurred in 55.3％,31.6％.Conclusions Combination of paclitaxol plus cisplatin is effective and tolerate in small cell lung cancer patients.