CAJ | 학술논문

小细胞肺癌对多种化疗药物产生的多药耐药特性是造成化疗失败的主要原因.小细胞肺癌产生多药耐药的机制涉及膜糖蛋白介导的药物外排机制、细胞内pH、ROS、HIF-1、GSH的改变,以及DNA损伤修复机制异常等.系统性分析小细胞肺癌多药耐药产生的机制,将有助于指导临床用药及为耐药逆转的新药研发提供理论依据.
소세포폐암대다충화료약물산생적다약내약특성시조성화료실패적주요원인.소세포폐암산생다약내약적궤제섭급막당단백개도적약물외배궤제、세포내pH、ROS、HIF-1、GSH적개변,이급DNA손상수복궤제이상등.계통성분석소세포폐암다약내약산생적궤제,장유조우지도림상용약급위내약역전적신약연발제공이론의거.
Multi-drug resistance is the main reason for chemotherapy failure of small cell lung cancer.Many factors are found to be related with multi-drug resistance,such as the overexpression of glycoprotein-mediated mechanism (P-gp,MRP,LRP),intracellular pH,ROS,HIF-1,GSH changes,DNA damage repair mechanisms abnormality.The comprehensive understanding of the multi-drug resistance mechanism of small cell lung cancer will help us to guide the usage of clinical drug and provide a theoretical basis for clinical resistance reversal.