国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
9期
663-665
,共3页
尤慧敏%沈大跃%李锋%付文江
尤慧敏%瀋大躍%李鋒%付文江
우혜민%침대약%리봉%부문강
血管生成因子2%慢性阻塞性肺疾病%生物标记物
血管生成因子2%慢性阻塞性肺疾病%生物標記物
혈관생성인자2%만성조새성폐질병%생물표기물
Angiopoietin-2%Chronic obstructive pulmonary disease%Biomarker
目的 研究患者血清中血管生成因子2(Ang2)浓度与慢性阻塞性肺疾病急性加重(AECOPD)之间的关系.方法 采用ELISA法检测血清中Ang2的浓度.血清标本分别来源于50例AECOPD患者,50例COPD稳定期患者和50名健康人.结果 AECOPD患者血清Ang2浓度是(3 861.6±273.8) ng/L,COPD稳定期患者Ang2浓度是(2 107.4±843.4) ng/L,健康人血清Ang2浓度是(1 645.7±453.2) ng/L. AECOPD患者血清中Ang2浓度显著高于COPD稳定期患者及健康人(P＜0.01).结论 AECOPD患者血清中Ang2浓度显著升高,Ang2有望成为评价AECOPD的一个有用的生物标记物.
目的 研究患者血清中血管生成因子2(Ang2)濃度與慢性阻塞性肺疾病急性加重(AECOPD)之間的關繫.方法 採用ELISA法檢測血清中Ang2的濃度.血清標本分彆來源于50例AECOPD患者,50例COPD穩定期患者和50名健康人.結果 AECOPD患者血清Ang2濃度是(3 861.6±273.8) ng/L,COPD穩定期患者Ang2濃度是(2 107.4±843.4) ng/L,健康人血清Ang2濃度是(1 645.7±453.2) ng/L. AECOPD患者血清中Ang2濃度顯著高于COPD穩定期患者及健康人(P＜0.01).結論 AECOPD患者血清中Ang2濃度顯著升高,Ang2有望成為評價AECOPD的一箇有用的生物標記物.
목적 연구환자혈청중혈관생성인자2(Ang2)농도여만성조새성폐질병급성가중(AECOPD)지간적관계.방법 채용ELISA법검측혈청중Ang2적농도.혈청표본분별래원우50례AECOPD환자,50례COPD은정기환자화50명건강인.결과 AECOPD환자혈청Ang2농도시(3 861.6±273.8) ng/L,COPD은정기환자Ang2농도시(2 107.4±843.4) ng/L,건강인혈청Ang2농도시(1 645.7±453.2) ng/L. AECOPD환자혈청중Ang2농도현저고우COPD은정기환자급건강인(P＜0.01).결론 AECOPD환자혈청중Ang2농도현저승고,Ang2유망성위평개AECOPD적일개유용적생물표기물.
Objective To study the relation between the serum angiopoietin-2 (Ang2) and acute exacerbation of chronic obstructive pulmonary diseases (AECOPD).Methods Using ELISA,serum concentration of Ang2 were measured in 50 patients with AECOPD,50 patients with stable COPD and 50 healthy control subjects.Results Serum Ang2 concentrations were (3 861.6 ± 273.8) ng/L in patients with AECOPD,(2 107.4±843.4) ng/L in patients with stable COPD and (1 645.7 ± 453.2) ng/L in healthy control subject.Serum Ang2 in patients with AECOPD were significantly higher in patients with AECOPD than both patients with stable COPD and healthy control subjects (P ＜0.01).Conclusions Serum Ang2 were significantly increased in AECOPD,and it might be a useful biomarker for this disease.
