CAJ | 학술논문

支气管哮喘(简称哮喘)和COPD两者的定义都表现为气流受限,但它们的危险因素及临床表现有所不同.然而,大量的临床观察发现哮喘患者表现出COPD表型,反过来,在COPD患者中也存在哮喘表型.流行病学资料表明老年慢性阻塞性气道疾病的患者中,一半或以上患者中存在哮喘和COPD重叠的现象,而这部分人被排除在目前各种临床药物试验之外.因此,对哮喘和COPD重叠的研究有助于更好地解决哮喘-COPD重叠患者的“特殊”临床特点,同时为COPD发病机制提供新的观点,亦为更好地预防、治疗及管理该重叠综合征作出最佳的选择.
지기관효천(간칭효천)화COPD량자적정의도표현위기류수한,단타문적위험인소급림상표현유소불동.연이,대량적림상관찰발현효천환자표현출COPD표형,반과래,재COPD환자중야존재효천표형.류행병학자료표명노년만성조새성기도질병적환자중,일반혹이상환자중존재효천화COPD중첩적현상,이저부분인피배제재목전각충림상약물시험지외.인차,대효천화COPD중첩적연구유조우경호지해결효천-COPD중첩환자적“특수”림상특점,동시위COPD발병궤제제공신적관점,역위경호지예방、치료급관리해중첩종합정작출최가적선택.
The risk factors and clinical manifestations between bronchial asthma (asthma) and chronic obstructive pulmonary disease (COPD) are different,although both of them are airflow obstruction in definition.However,a large number of clinical observations show patients with asthma present with COPD phenotype,in turn,patients with COPD also coexist with asthma phenotype.The epidemiological data show that half or more of old patients with COPD exist asthma-COPD overlap phenomenon,while those patients are excluded from clinical trials of " pure" asthma or COPD.Therefore,the study of overlap syndrome between asthma and COPD helps to resolve the "special" clinical characteristics for those patients and provides a new perspective for the pathogenesis of COPD,it also makes better choice for the prevention,treatment and management of the overlap.