CAJ | 학술논문

由于肺栓塞非特异性的临床表现,COPD的患者出现呼吸困难症状时可能是一大临床挑战.典型的发热、刺激性咳嗽、喘息症状支持COPD急性发作,然而当缺乏此类表现时可能有必要进一步评估潜在的病因,包括肺血栓栓塞症.为了进一步提高其诊断率及疗效和预后,本文综述了COPD和肺血栓栓塞症的流行病学及病理生理、临床表现、辅助检查、评价手段等,并提出了对已知阻塞性肺疾病患者发生血栓栓塞症研究工作开展的基本原理概述.未来有望建立一套安全有效的评价体系及合理的治疗方案,以便更好地指导临床工作.
유우폐전새비특이성적림상표현,COPD적환자출현호흡곤난증상시가능시일대림상도전.전형적발열、자격성해수、천식증상지지COPD급성발작,연이당결핍차류표현시가능유필요진일보평고잠재적병인,포괄폐혈전전새증.위료진일보제고기진단솔급료효화예후,본문종술료COPD화폐혈전전새증적류행병학급병리생리、림상표현、보조검사、평개수단등,병제출료대이지조새성폐질병환자발생혈전전새증연구공작개전적기본원리개술.미래유망건립일투안전유효적평개체계급합리적치료방안,이편경호지지도림상공작.
Dyspnea in patients with known chronic obstructive pulmonary disease (COPD) can be a clinical challenge due to the nonspecific nature of atypical presentations.Typical features of fever,productive cough,and wheezing on presentation support COPD exacerbation,while absence of such findings may warrant further evaluation for underlying etiologies,including pulmonary embolism (PTE).In order to further improve the diagnosis rate and the efficacy and prognosis of COPD patients with PTE,This review discusses the prevalence、pathophysiology、clinical presentation、ancillary testing and evaluation tools of COPD with PTE,and presents an overview of the rationale for pursuing work-up for thromboembolic disease in the setting of known obstructive lung diseases.The future is expected to establish a safe and effective evaluation system and reasonable treatment programs in order to better guide clinical work.