国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2014年
2期
100-106
,共7页
耐甲氧西林金黄色葡萄球菌%生物膜%感染%防治
耐甲氧西林金黃色葡萄毬菌%生物膜%感染%防治
내갑양서림금황색포도구균%생물막%감염%방치
Methicillin-resistant Staphylococcus aureus%Biofilm%Infection%Therapeutic strategies
耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)感染的流行使其成为医院和社区获得性感染的重要致病菌,MRSA具有传播速度快、流行范围广、多部位感染、多耐药性特点,与乙型肝炎、艾滋病并称当今世界三大感染顽疾.而MRSA生物膜的形成使感染慢性化并难以控制,为临床防治带来极大困难.本文对MRSA生物膜的形成过程、群体感应系统、致病性及耐药机制、防治策略进行综述.充分认识和理解其发生发展规律、治疗策略及临床重要性具有十分重要的意义.
耐甲氧西林金黃色葡萄毬菌(methicillin-resistant Staphylococcus aureus,MRSA)感染的流行使其成為醫院和社區穫得性感染的重要緻病菌,MRSA具有傳播速度快、流行範圍廣、多部位感染、多耐藥性特點,與乙型肝炎、艾滋病併稱噹今世界三大感染頑疾.而MRSA生物膜的形成使感染慢性化併難以控製,為臨床防治帶來極大睏難.本文對MRSA生物膜的形成過程、群體感應繫統、緻病性及耐藥機製、防治策略進行綜述.充分認識和理解其髮生髮展規律、治療策略及臨床重要性具有十分重要的意義.
내갑양서림금황색포도구균(methicillin-resistant Staphylococcus aureus,MRSA)감염적류행사기성위의원화사구획득성감염적중요치병균,MRSA구유전파속도쾌、류행범위엄、다부위감염、다내약성특점,여을형간염、애자병병칭당금세계삼대감염완질.이MRSA생물막적형성사감염만성화병난이공제,위림상방치대래겁대곤난.본문대MRSA생물막적형성과정、군체감응계통、치병성급내약궤제、방치책략진행종술.충분인식화리해기발생발전규률、치료책략급림상중요성구유십분중요적의의.
The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection makes it as an important pathogen for hospital-and community-acquired infections. MRSA spreads fast and widely with multi-site infection and multi-drug resistance. MRSA, hepatitis B and AIDS are called the three leading refractory infections in the world nowadays. The formation of MRSA biofilm makes the infection to be chronic and difficult to control and brings great difficulties for clinical treatment. The formation process of MRSA biofilm, the quorum sensing system, pathogenicity and resistance mechanisms of MRSA,and control strategies are discussed in the article. It is of great significance to fully understand the evolution nature, the therapeutic strategies and be alert of its increasing clinical importance.
