CAJ | 학술논문

蒙特卡洛模拟是一种概率分析方法,可以对单一或混合因素进行模拟.本综述介绍蒙特卡洛模拟用于各类抗菌药物药效学研究中,预测和评价抗菌效果,优化给药方案,为指导临床用药提供了科学、有力的数学依据.蒙特卡洛模拟为临床抗菌药物药效学研究与评价开辟了新思路、新方法.蒙特卡洛模拟抗菌药物药效在国外得到广泛的应用,而在国内应用很少,旨在大力推广,以便更好地指导临床安全、合理用药.
몽특잡락모의시일충개솔분석방법,가이대단일혹혼합인소진행모의.본종술개소몽특잡락모의용우각류항균약물약효학연구중,예측화평개항균효과,우화급약방안,위지도림상용약제공료과학、유력적수학의거.몽특잡락모의위림상항균약물약효학연구여평개개벽료신사로、신방법.몽특잡락모의항균약물약효재국외득도엄범적응용,이재국내응용흔소,지재대력추엄,이편경호지지도림상안전、합리용약.
Monte Carlo simulation is a probabality analytical method,which can simulate single or admixture factors.The present overview introduces the use of Monte Carlo simulation on the investigation of many antibacterials pharmacodynamics to optimize dosage regimen, forecasting and evaluating antibacterial effect.The method provides a scientific and forcible mathematics evidence for clinical medication. Monte Carlo simulation establishes the new ideas and method for the investigation and evaluation on clinical antibacterials pharmacodynamics. Monte Carlo simulation is widely used for simulating antibacterials pharmacodynamic abroad,but in china it is rarely employed,so the aim of the overview is vigorously generalizing this method in order to preferably guide clinical safe and rational adminisration.