CAJ | 학술논문

Rho鸟苷酸解离抑制因子-2(RhoGDI2)是小G蛋白调节因子家族成员之一,调控多种小G蛋白的生物学活性.它对Rho蛋白有双重调节作用,并从上游调节鸟苷酸交换因子、GTP酶活化蛋白的活性.目前研究表明RhoGDI2影响肿瘤侵袭转移,在多种恶性肿瘤中的异常表达将参与肿瘤的发生发展.研究RhoGDI2将有助于加深对肿瘤侵袭转移机制的了解,为预防肿瘤转移提供特异性、多靶位的治疗方法.另外,RhoGDI2在β2肾上腺素能受体(β2AR)减敏的哮喘小鼠肺组织中高表达,研究RhoGDI2和β2AR的关系为临床防治β2AR减敏提供一个新的切入点和治疗方向.
Rho조감산해리억제인자-2(RhoGDI2)시소G단백조절인자가족성원지일,조공다충소G단백적생물학활성.타대Rho단백유쌍중조절작용,병종상유조절조감산교환인자、GTP매활화단백적활성.목전연구표명RhoGDI2영향종류침습전이,재다충악성종류중적이상표체장삼여종류적발생발전.연구RhoGDI2장유조우가심대종류침습전이궤제적료해,위예방종류전이제공특이성、다파위적치료방법.령외,RhoGDI2재β2신상선소능수체(β2AR)감민적효천소서폐조직중고표체,연구RhoGDI2화β2AR적관계위림상방치β2AR감민제공일개신적절입점화치료방향.
Rho GDP dissociation inhibitor 2 (RhoGDI2) is one of the member of small G protein regulatory factor family.It regulates the biological activity of multiple small G protein. It has bidirectional regulations on Rho protein, and regulates the activities of guanine nucleotide exchange factors and GTPase-activating proteins. The currently studies have shown that RhoGDI2 affects the tumor invasion and metastasis, it is abnormally expressed in a variety of malignant tumors and involved in the occurrence and development of tumors. Studies on RhoGDI2 may deepen our understanding on the mechanism of tumor invasion, which provide specific and multi-target therapy for the prevention of tumor metastasis. In addition, RhoGDI2 is overexpressed in the lung of asthma mice with β2 adrenergic receptor (β2AR) desensitization. Thus, investigating the relationship between RhoGDI2 and β2AR will provide a new direction and therapy for management of β2AR desensitization.