CAJ | 학술논문

人软骨糖蛋白-39(YKL-40)是一种新发现的炎症因子,属于哺乳动物18-糖基水解酶家族成员.既往研究表明,YKL-40与炎症和肿瘤有关.近年来研究显示,YKL-40可能参与了支气管哮喘(简称哮喘)的发生、发展,并且与气道重塑密切相关.YKL-40的生物学功能和作用尚不完全清楚,可能均参与了哮喘的炎症反应、气道高反应性、气道重塑的过程.YKL-40对于检测哮喘患者的辅助检查、严重程度、预后判断均有一定的意义.
인연골당단백-39(YKL-40)시일충신발현적염증인자,속우포유동물18-당기수해매가족성원.기왕연구표명,YKL-40여염증화종류유관.근년래연구현시,YKL-40가능삼여료지기관효천(간칭효천)적발생、발전,병차여기도중소밀절상관.YKL-40적생물학공능화작용상불완전청초,가능균삼여료효천적염증반응、기도고반응성、기도중소적과정.YKL-40대우검측효천환자적보조검사、엄중정도、예후판단균유일정적의의.
Human cartilage glycoprotein 39 (YKL-40) is a newly discovered inflammatory cytokine,which belongs to the member of 18 glycosyl hydrolase of mammal family.Previous studies have indicated that YKL-40 is associated with the inflammation disease and tumors.Studies in recent years have suggested that YKL-40 may be involved in the occurrence of asthma and development,and is related to airway remodeling.The biological function and role of YKL-40 is not yet fully understood.It is possible involved in the inflammatory response of asthma,airway hyperresponsiveness,airway remodeling process.The detection of YKL-40 may have some significance in the aided diagnosis,asthma severity and predicting prognosis.