CAJ | 학술논문

支气管哮喘(简称哮喘)是一种气道的慢性炎症性疾病,许多类型的细胞起到了重要作用,特别是肥大细胞、嗜酸粒细胞和T淋巴细胞.气道高反应性、炎症和重塑是哮喘的主要特征.气道重塑的特点包括上皮下纤维化,成纤维细胞增生,肌细胞增生和肥大,连同上皮细胞损伤杯状细胞化生、水肿和血管增加.气道高反应性与气道重塑和气道炎症密切相关.整合素作为一类黏附分子的受体是多功能蛋白质,把细胞连接到细胞外基质和组织细胞边缘的整合素黏附复合物.它还控制着细胞的命运和功能,通过影响细胞的增殖、凋亡和分化.各种各样的整合素异二聚体是从9种β亚基和24种a亚基组合形成的.他们是异二聚体,作用是细胞外基质和肌动蛋白骨架的横跨膜的连接器.整合素还作为信号转换器,当矩阵绑定激活时激活各种细胞内信号转导通路.整合素和常规的信号受体经常合作,促进细胞生长,细胞存活,细胞增殖.而近年来对不同整合素与哮喘相关性的研究越来越多,以下就对不同整合素进行阐述.
지기관효천(간칭효천)시일충기도적만성염증성질병,허다류형적세포기도료중요작용,특별시비대세포、기산립세포화T림파세포.기도고반응성、염증화중소시효천적주요특정.기도중소적특점포괄상피하섬유화,성섬유세포증생,기세포증생화비대,련동상피세포손상배상세포화생、수종화혈관증가.기도고반응성여기도중소화기도염증밀절상관.정합소작위일류점부분자적수체시다공능단백질,파세포련접도세포외기질화조직세포변연적정합소점부복합물.타환공제착세포적명운화공능,통과영향세포적증식、조망화분화.각충각양적정합소이이취체시종9충β아기화24충a아기조합형성적.타문시이이취체,작용시세포외기질화기동단백골가적횡과막적련접기.정합소환작위신호전환기,당구진방정격활시격활각충세포내신호전도통로.정합소화상규적신호수체경상합작,촉진세포생장,세포존활,세포증식.이근년래대불동정합소여효천상관성적연구월래월다,이하취대불동정합소진행천술.
Bronchial asthma (asthma) is a chronic inflammatory disease of the airways in which many cell types play a role,in particular mast cells,eosinophils and Tlymphocytes.Airway hyperresponsiveness,inflammation and remodeling are the key feature of asthma.The characteristics of airway remodelling include subepithelial fibrosis,myofibroblast hyperplasia,myocyte hyperplasia and hypertrophy,together with epithelial damage,goblet cell metaplasia,oedema and increased vascularity.Airway hyperresponsiveness is associated with features of both remodelling and airway inflammation.Integrins,which constitute one class of cell-adhesion receptor,are multifunctional proteins that link cells to the extracellular matrix and organise integrin adhesion complexes at the cell periphery.Integrins also control the fate and function of cells by influencing their proliferation,apoptosis and differentiation.A variety of human integrin heterodimers are formed from 9 types of β subunits and 24 types of α subunits.They are heterodimers and function as transmembrane linkers between the extracellular matrix and the actin cytoskeleton nction as signal transducers,activating various intracellular signaling pathways when activated by matrix binding.Integrins and conventional signaling receptors often cooperate to promote cell growth,cell survival,and cell proliferation.In recent years different integrin associated with asthma research more and more,the paper elaborated following different integrin.