CAJ | 학술논문

抗菌肽是宿主防御系统的重要组成部分.在人气道上皮中主要表达2种阳离子小分子抗菌肽,即防御素和cathelicidins/LL-37,它们通过直接杀菌、调节天然或适应性免疫、损伤修复等生物学活性对抗肺部常见病原体的侵袭.本文就防御素和cathelicidins/LL-37的来源及结构特征、表达调节、在肺部抗感染免疫防御中的作用进行综述.
항균태시숙주방어계통적중요조성부분.재인기도상피중주요표체2충양리자소분자항균태,즉방어소화cathelicidins/LL-37,타문통과직접살균、조절천연혹괄응성면역、손상수복등생물학활성대항폐부상견병원체적침습.본문취방어소화cathelicidins/LL-37적래원급결구특정、표체조절、재폐부항감염면역방어중적작용진행종술.
Antimicrobial protein/peptides (AMPs) are an important part of the defense system.Defensins and cathelicidins/LL-37 are the two main small cationic AMPs which are present in airway epithelial cells.AMPs play a critical role in resisting pathongens of invading lung through direct antimicrobial activity,modulating innate or adaptive immunity,and wound repair.The orign and architectural feature,expression regulation and research progress in pulmonary anti-infection immune defense of defensins and cathelicidins/LL-37 are reviewed here.